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Acute bacterial meningitis in adults. A review of 493 episodes.
TLDR
In the authors' large urban hospital, a major proportion of cases of acute bacterial meningitis in adults were nosocomial, and recurrent episodes of meningococcus pneumoniae and Neisseria meningitidis were frequent.
Infective endocarditis in adults.
TLDR
This review article provides a comprehensive assessment of this serious infectious disease, including diagnostic challenges, cardiovascular and neurologic complications, and approaches to therapy.
The origin of the Haitian cholera outbreak strain.
TLDR
The Haitian epidemic is probably the result of the introduction, through human activity, of a V. cholerae strain from a distant geographic source, and analysis of genomic variation of the Haitian isolates reveals a more distant relationship with circulating South American isolates.
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
TLDR
It is shown that the mechanisms that govern the aging and immune function in Caenorhabditis elegans and the human Gram-negative bacterial pathogens Pseudomonas aeruginosa may be interrelated.
Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
TLDR
A gene cluster in El Tor Vibrio cholerae that encodes a cytotoxic activity for HEp-2 cells in vitro is identified and characterized and may be associated with residual adverse properties displayed by certain live, attenuated cholera vaccines.
A simple model host for identifying Gram-positive virulence factors
TLDR
The use of the nematode Caenorhabditis elegans is demonstrated as a facile and inexpensive model host for several Gram-positive human bacterial pathogens and an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis is exploited.
Role of iron in regulation of virulence genes
TLDR
Studies of the mechanisms of regulation of iron acquisition systems and virulence determinants by iron should lead to a better understanding of the adaptive response of bacteria to the low-iron environment of the host and its importance in virulence.
Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients
TLDR
RBD-targeted antibodies are excellent markers of previous and recent infection, that differential isotype measurements can help distinguish between recent and older infections, and that IgG responses persist over the first few months after infection and are highly correlated with neutralizing antibodies.
Central Nervous System Infection with Listeria monocytogenes : 33 Years' Experience at a General Hospital and Review of 776 Episodes from the Literature
TLDR
Compared with patients with acute meningitis due to other bacterial pathogens, patients with Listeria infection had a significantly lower incidence of meningeal signs, and the CSF profile was significantly less likely to have a high WBC count or a high protein concentration.
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