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Acute bacterial meningitis in adults. A review of 493 episodes.
BACKGROUND AND METHODS To characterize acute bacterial meningitis in adults, we reviewed the charts of all persons 16 years of age or older in whom acute bacterial meningitis was diagnosed atExpand
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Infective endocarditis in adults.
The clinical features of this complex infection have changed in the past several decades. It is now an infection of older people, and mitral-valve prolapse is the most common predisposingExpand
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Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
Our laboratories have studied the mechanisms of aging ( [1][1], [2][2] ) and immune function ( [3][3] ) in Caenorhabditis elegans . Herein we show that the mechanisms that govern these two processesExpand
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A simple model host for identifying Gram-positive virulence factors
We demonstrate the use of the nematode Caenorhabditis elegans as a facile and inexpensive model host for several Gram-positive human bacterial pathogens. Enterococcus faecalis, StreptococcusExpand
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The origin of the Haitian cholera outbreak strain.
BACKGROUND Although cholera has been present in Latin America since 1991, it had not been epidemic in Haiti for at least 100 years. Recently, however, there has been a severe outbreak of cholera inExpand
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Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage.
We identify and characterize a gene cluster in El Tor Vibrio cholerae that encodes a cytotoxic activity for HEp-2 cells in vitro. This gene cluster contains four genes and is physically linked to theExpand
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Role of iron in regulation of virulence genes.
The abilities of bacterial pathogens to adapt to the environment within the host are essential to their virulence. Microorganisms have adapted to the iron limitation present in mammalian hosts byExpand
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Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.
We used plants as an in vivo pathogenesis model for the identification of virulence factors of the human opportunistic pathogen Pseudomonas aeruginosa. Nine of nine TnphoA mutant derivatives of P.Expand
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Central Nervous System Infection with Listeria monocytogenes : 33 Years' Experience at a General Hospital and Review of 776 Episodes from the Literature
We reviewed 776 previously reported and 44 new cases of CNS listeriosis outside of pregnancy and the neonatal period, and evaluated the epidemiologic, diagnostic, and therapeutic characteristics ofExpand
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