Share This Author
Crystal Structure of a Lipid G Protein–Coupled Receptor
The crystal structure of the sphingosine 1-phosphate receptor 1 fused to T4-lysozyme in complex with an antagonist sphingolipid mimic provides a detailed view of the molecular recognition and requirement for hydrophobic volume that activates S1P1, resulting in the modulation of immune and stromal cell responses.
Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
- Sanjeev S. Ranade, Zhaozhu Qiu, A. Patapoutian
- BiologyProceedings of the National Academy of Sciences
- 23 June 2014
It is demonstrated that Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow, which suggests a potential role forPiezo1 in mechanotransduction in adult cardiovascular function and disease.
Piezo1 links mechanical forces to red blood cell volume
- S. Cahalan, V. Lukacs, Sanjeev S. Ranade, S. Chien, M. Bandell, A. Patapoutian
- 1 May 2015
It is shown that RBCs exhibit robust calcium entry in response to mechanical stretch and that this entry is dependent on Piezo1 expression, which plays an essential role in RBC volume homeostasis.
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
It is found that all PIEZO1 mutations give rise to mechanically activated currents that inactivate more slowly than wild-type currents, providing insight that helps to explain the increased permeability of cations in RBCs of DHS patients.
Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia
This work identifies biallelic mutations in PIEZO1 (a splicing variant leading to early truncation and a non-synonymous missense variant) in a pair of siblings affected with persistent lymphoedema caused by congenital lymphatic dysplasia and delineates a novel clinical category of PIEzO1-associated hereditary lymphOedema.
Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection
GPR68 Senses Flow and Is Essential for Vascular Physiology