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Palladium reagents and catalysts: Innovation on Organic synthesis
The Basic Chemistry of Organopalladium Compounds. Classification of the Reactions Involving Pd(II) Compounds and Pd(0) Complexes in This Book. Oxidative Reactions with Pd(II) Compounds. CatalyticExpand
Microwave assisted organic reactions
Optical control of trimeric P2X receptors and acid-sensing ion channels
A thiol-reactive, light-sensitive azobenzene molecule that can attach between cysteines introduced by mutagenesis into different channel subunits is designed that will allow precise optical control of P2X receptors or ASICs in intact tissues. Expand
Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
The use of mono- and dibromomaleimides for reversible cysteine modification and illustration on the SH2 domain of the Grb2 adaptor protein (L111C) highlight the significant potential for this new class of reagents in protein modification. Expand
Recent advances in the construction of antibody-drug conjugates.
The strategies currently used for the site-specific construction of ADCs are discussed and their merits and disadvantages are appraised. Expand
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy
A significant step towards a platform for next-generation antibody-based therapeutics is described by providing constructs that combine site-specific modification, exceptional versatility and high stability, with retention of antibody binding and structure post-modification. Expand
A generic approach for the catalytic reduction of nitriles
The scope of nickel boride mediated reduction of nitriles has been extended further to allow the preparation of Boc protected amines via a mild catalytic process. It is noteworthy that the toxicityExpand
Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'
3,4-substituted maleimides are used to bridge and thus functionalize disulfide bonds to generate homogeneous antibody conjugates to detect antigen with a spin labeled antibody fragment by continuous-wave electron paramagnetic resonance (cw-EPR), which is reported here for the first time. Expand
Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment.
This work describes the attachment of azide-functionalized, water-soluble porphyrins to a tratuzumab Fab fragment via a novel conjugation methodology that allows for the synthesis of a homogeneous product without the loss of structural stability associated with conventional methods of disulfide modification. Expand
Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.
A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterialExpand