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Isolation and characterization of nitrogen mustard-sensitive mutants of Chinese hamster ovary cells.
Radioprotective action of WR-1065 on radiation-induced DNA strand breaks in cultured Chinese hamster ovary cells.
It would appear that the molecular actions of aminothiol radioprotective compounds that lead to reduced cell killing are much more complex than previously thought.
Cell survival and recovery processes in Chinese hamster AA8 cells and in two radiosensitive clones.
Although both SLD and PLD recovery play a role in determining cell survival, cell-survival curve parameters may not always be useful in predicting cellular recovery capacity.
The induction of DNA-protein crosslinks in hypoxic cells and their possible contribution to cell lethality.
The induction of single-strand breaks (SSBs) in the DNA of Chinese hamster ovary cells by X rays under different irradiation conditions was measured by the alkaline elution technique, suggesting that DNA-protein crosslinks (DPCs) are preferentially produced in hypoxic cells by radiation.
Applicability of the alkaline elution procedure as modified for the measurement of DNA damage and its repair in nonradioactively labeled cells.
Relationship between the repair of radiation-induced DNA damage and recovery from potentially lethal damage in 9L rat brain tumor cells.
The kinetics of repair of radiation-induced DNA damage and recovery from radiation-induced potentially lethal damage (PLD) for fed plateau-phase 9L/Ro rat brain tumor cells were compared after single…
Induction and rejoining of gamma-ray-induced DNA single- and double-strand breaks in Chinese hamster AA8 cells and in two radiosensitive clones.
The results indicate that radiosensitive EM9 cells, whose kinetics of recovery from SLD and PLD was the same as that of AA8 cells, have a defect in the fast phase of SSB rejoining but no measurable defect in DSB rejoining, and there is no direct correlation between either of these recovery processes and the rejoining of SSBs or DSBs as assayed here.
Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation.
All three thiols protected against ssb induction, although to a significantly lower extent than against cell killing measured under identical conditions, and each thiol also protected against dsb induction.
Radioprotection of cultured Chinese hamster ovary cells by WR-255591.
- D. Murray, E. Altschuler, M. Kerr, S. C. Vanankeren, R. Meyn, L. Milas
- BiologyInternational journal of radiation biology
The observation of lower PFs for DNA strand breaks than for cell survival suggests that radioprotection by WR-255591 probably does not result from a uniform decrease in the induction of all types of DNA lesions, rather, the drug may differentially protect againstThe induction of subclasses of DNA damage.
Variations in the spectrum of lesions produced in the DNA of cells from mouse tissues after exposure to gamma-rays in air-breathing or in artificially anoxic animals.
- D. Murray, R. Meyn, S. C. Vanankeren
- Biology, MedicineInternational journal of radiation biology and…
- 1 June 1988
Gamma-ray-induced DNA-protein crosslinks are preferentially induced in cultured cells irradiated at very low oxygen tensions, and the effects of proteinase K on the DNA elution rate for normal mouse tissues may be complex.