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Methods for state-of-charge determination and their applications
Abstract State-of-charge (SOC) determination becomes an increasingly important issue in all the applications that include a battery. Former operation strategies made use of voltage limits only toExpand
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Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology.
The small HIV-1 accessory protein Vpr (virus protein R) is a multifunctional protein that is present in the serum and cerebrospinal fluid of AIDS patients. We previously showed that Vpr can formExpand
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The Amino-Terminal Region of Vpr from Human Immunodeficiency Virus Type 1 Forms Ion Channels and Kills Neurons
ABSTRACT We have previously reported that the accessory protein Vpr from human immunodeficiency virus type 1 forms cation-selective ion channels in planar lipid bilayers and is able to depolarizeExpand
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Mutational Analysis of Conserved Domains within the Cytoplasmic Tail of gp41 from Human Immunodeficiency Virus Type 1: Effects on Glycoprotein Incorporation and Infectivity
ABSTRACT The transmembrane (TM) glycoprotein gp41 of human immunodeficiency virus type 1 possesses an unusually long (∼150 amino acids) and highly conserved cytoplasmic region. Previous studies inExpand
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The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.
The HIV p17 or matrix (MA) protein has long been implicated in the process of nuclear import of the HIV genome and thus the ability of the virus to infect nondividing cells such as macrophages. WhileExpand
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Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.
A small (96-aa) protein, virus protein R (Vpr), of human immunodeficiency virus type 1 contains one hydrophobic segment that could form a membrane-spanning helix. Recombinant Vpr, expressed inExpand
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Protein methylation is required to maintain optimal HIV-1 infectivity
Background:Protein methylation is recognized as a major protein modification pathway regulating diverse cellular events such as protein trafficking, transcription, and signal transduction. MoreExpand
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Photochemical tissue bonding with chitosan adhesive films
A new biocompatible chitosan adhesive has been developed that bonds photochemically to tissue with minimal temperature increase. Expand
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Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?
Current treatments against the Aquired immune deficiency syndrome (AIDS) are reasonably effective in reducing the amount of human immunodeficiency virus (HIV) present in infected patients, but theirExpand
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Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication.
One hallmark of AIDS progression is a decline in CD4+ T lymphocytes, though the mechanism is poorly defined. There is ample evidence that increased apoptosis is responsible for some, if not all, ofExpand
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