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Polo-like kinases: structural variations lead to multiple functions
Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression, centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo major changes inExpand
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BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair.
Cilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localizedExpand
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A mechanism for the elimination of the female gamete centrosome in Drosophila melanogaster
INTRODUCTION Centrioles are small microtubule-based cellular structures that are critical for cilia and centrosome assembly. During successful fertilization in animals, centrioles are asymmetricallyExpand
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Mapping molecules to structure: unveiling secrets of centriole and cilia assembly with near-atomic resolution.
Centrioles are microtubule (MT)-based cylinders that form centrosomes and can be modified into basal bodies that template the axoneme, the ciliary MT skeleton. These MT-based structures are presentExpand
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PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space.
Centrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centrioleExpand
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Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila
Drosophila Rootletin organizes rootlets in sensory neurons, where it transmits multiple sensory inputs and maintains basal body cohesion, yet it is not required for cilium stability.
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Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number
Polo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification. The SCF-Slimb/βTrCP-E3 ubiquitin ligaseExpand
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KAP, the accessory subunit of kinesin-2, binds the predicted coiled-coil stalk of the motor subunits.
Kinesin-2 is an anterograde motor involved in intraflagellar transport and certain other intracellular transport processes. It consists of two different motor subunits and an accessory protein KAPExpand
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Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation
Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence,Expand
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Drosophilamelanogaster as a model for basal body research
The fruit fly, Drosophila melanogaster, is one of the most extensively studied organisms in biological research and has centrioles/basal bodies and cilia that can be modelled to investigate theirExpand
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