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Evidence for a new angiotensin-(1–7) receptor subtype in the aorta of Sprague–Dawley rats
We have recently described, in the mouse aorta, the vasodilator effect of angiotensin-(1-7) (Ang-(1-7)) was mediated by activation of the Mas Ang-(1-7) receptor and that A-779 and D-Pro7-Ang-(1-7)Expand
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Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.
In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial nitric oxide synthase (eNOS)-derived NO production. However, we have recently shown that neuronal nitric oxideExpand
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Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function.
The venom of the spider Phoneutria nigriventer contains several toxins that have bioactivity in mammals and insects. Accidents involving humans are characterized by various symptoms including penileExpand
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The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue.
The inhibitory effect of the flavonoid dioclein was assessed on purified vascular cyclic nucleotide phosphodiesterase isoforms (EC 3.1.4.17, PDE1-5) in comparison withExpand
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Hancornia speciosa Gomes induces hypotensive effect through inhibition of ACE and increase on NO.
ETHNOPHARMACOLOGICAL RELEVANCE The leaves of Hancornia speciosa Gomes are popularly used in Brazil to treat diabetes and hypertension. Cardiovascular diseases are the main cause of death worldwideExpand
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Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor.
Endothelium-dependent vasorelaxation in large vessels is mainly attributed to Nomega-nitro-L-arginine methyl ester (L-NAME)-sensitive endothelial nitric oxide (NO) synthase (eNOS)-derived NOExpand
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Validation of a colorimetric assay for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE) from plant extracts.
A new method for the in vitro screening of plant extracts with potential angiotensin-converting enzyme (ACE) inhibitory activity is proposed. The method is based on the cleavage of the substrateExpand
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Endothelium dysfunction in LDL receptor knockout mice: a role for H2O2
In this study, the role of endogenous H2O2 as an endothelium‐dependent relaxant factor was characterised in aortas from C57BL/6J and LDL receptor‐deficient mice (LDLR−/−). Aortic rings from LDLR−/−Expand
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Phosphatidylinositol 3‐kinase‐δ up‐regulates L‐type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning in diabetes is associated with abnormal vasoconstriction and Ca2+Expand
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Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries
The hypotensive and vasorelaxant effect of dioclein in resistance mesenteric arteries was studied in intact animals and isolated vessels, respectively. In intact animals, initial bolus administrationExpand
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