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Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships
- S. Reutzel-Edens, Julie Kay Bush, P. A. Magee, G. Stephenson, S. Byrn
- Materials Science, Chemistry
- 2 July 2003
Olanzapine, a novel benzodiazepine agent used in the treatment of schizophrenia and related psychoses, crystallizes in 25+ crystal forms, seven of which are pharmaceutically relevant: three…
Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations
- S. Byrn, R. Pfeiffer, Michael E. Ganey, C. Hoiberg, G. Poochikian
- Medicine, Materials SciencePharmaceutical Research
- 1 July 1995
It is hoped that this review will lead to a more direct approach to the characterization of pharmaceuticalsolids and ultimately to faster approval of regulatory documents containing information on pharmaceutical solids.
Chemical reactivity in solid-state pharmaceuticals: formulation implications.
A Calorimetric Method to Estimate Molecular Mobility of Amorphous Solids at Relatively Low Temperatures
- Chen Mao, Sai Prasanth Chamarthy, S. Byrn, R. Pinal
- Materials Science, ChemistryPharmaceutical Research
- 24 August 2006
The proposed calorimetry-based approach can be used to estimate molecular mobility at relatively low temperatures without having to conduct enthalpy recovery experiments and relies on faithful fragility measurements.
Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications.
This review focuses on the use of solid-state NMR techniques for the characterization of pharmaceutical solids (drug substance and dosage form) through methods for studying structure and conformation, analyzing molecular motions, and measuring internuclear distances.
Physical characteristics and chemical degradation of amorphous quinapril hydrochloride.
It appears that agglomeration and sintering of particles caused by softening of the solid, particularly above T(g), and a resulting reduction of the particle surface/volume ratio play a major role in affecting the reaction rate by decreasing the rate of removal of the gaseous HCl product.
Solid-state pharmaceutical chemistry
Solid-state analysis of the active pharmaceutical ingredient in drug products.
Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength
G glycine crystallization during freezing of aqueous solutions as a function of the glycine salt form, pH, and ionic strength is characterized to underscore the importance of recognizing that seemingly minor changes in formulation conditions can have profound effects on the physical chemistry of freezing and freeze drying.