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Solid state chemistry of drugs
Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships
Olanzapine, a novel benzodiazepine agent used in the treatment of schizophrenia and related psychoses, crystallizes in 25+ crystal forms, seven of which are pharmaceutically relevant:  threeExpand
Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations
It is hoped that this review will lead to a more direct approach to the characterization of pharmaceuticalsolids and ultimately to faster approval of regulatory documents containing information on pharmaceutical solids. Expand
Chemical reactivity in solid-state pharmaceuticals: formulation implications.
Solid-state reactions that occur in drug substances and formulations include solid-state phase transformations, dehydration/desolvation, and chemical reactions, which are of particular interest in cases where the drug-substance may be unstable or react with excipients in the formulation. Expand
Solid-state analysis of the active pharmaceutical ingredient in drug products.
The solid form of a drug substance is important when developing a new chemical entity based on possible manufacturability, solubility, bioavailability and stability differences between the solid forms. Expand
A Calorimetric Method to Estimate Molecular Mobility of Amorphous Solids at Relatively Low Temperatures
The proposed calorimetry-based approach can be used to estimate molecular mobility at relatively low temperatures without having to conduct enthalpy recovery experiments and relies on faithful fragility measurements. Expand
Physical characteristics and chemical degradation of amorphous quinapril hydrochloride.
It appears that agglomeration and sintering of particles caused by softening of the solid, particularly above T(g), and a resulting reduction of the particle surface/volume ratio play a major role in affecting the reaction rate by decreasing the rate of removal of the gaseous HCl product. Expand
Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications.
This review focuses on the use of solid-state NMR techniques for the characterization of pharmaceutical solids (drug substance and dosage form) through methods for studying structure and conformation, analyzing molecular motions, and measuring internuclear distances. Expand
Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength
G glycine crystallization during freezing of aqueous solutions as a function of the glycine salt form, pH, and ionic strength is characterized to underscore the importance of recognizing that seemingly minor changes in formulation conditions can have profound effects on the physical chemistry of freezing and freeze drying. Expand