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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
TLDR
It is found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1.
A mechanism for initiating RNA-dependent RNA polymerization
TLDR
The results provide a working model for the initiation of replication and transcription of double-stranded RNA viruses and flaviviruses and suggest a mechanism by which the incoming double-Stranded RNA is opened up to feed the template through to the active site, while the substrates enter by another route.
Insights into assembly from structural analysis of bacteriophage PRD1
TLDR
The architectural similarities with adenovirus and one of the largest known virus particles PBCV-1 support the notion that the mechanism of assembly of PRD1 is scaleable and applies across the major viral lineage formed by these viruses.
Structure and host-cell interaction of SH1, a membrane-containing, halophilic euryarchaeal virus
TLDR
The results indicate that SH1 has a complex capsid formed from single β-barrels, an important missing link in hypotheses on viral capsid protein evolution, and unusual, symmetry-mismatched spikes seem to play a role in host adsorption.
Architecture of respiratory syncytial virus revealed by electron cryotomography
TLDR
An electron cryotomographic characterization of cell culture-grown human respiratory syncytial virus is carried out to determine the architecture of the virion and indicates important differences in structure between the Paramyxovirinee and Pneumovirinae subfamilies within the Par amyxviridae.
Electron Cryotomography of Tula Hantavirus Suggests a Unique Assembly Paradigm for Enveloped Viruses
TLDR
The structure and assembly principles of Tula hantavirus exemplify a unique assembly paradigm for enveloped viruses.
Structure of the archaeal head-tailed virus HSTV-1 completes the HK97 fold story
TLDR
The HK97-like lineage is expanded to include archaeal, bacterial, and eukaryotic viruses, supporting the hypothesis that the last common universal ancestor of cellular organisms was infected by a number of different viruses.
Insights into Head-Tailed Viruses Infecting Extremely Halophilic Archaea
TLDR
It is shown that these viruses are inactivated, yet remain intact, at low salinity and that their infectivity is regained when high salinity is restored, and that rigorous comparisons with bacteriophages are not yet warranted.
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