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Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats
To compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium‐based contrast agents (GBCAs)
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
TLDR
The No Observed Adverse Effect Level (NOAEL) for general toxicity of dams and embryo-fetal development was 0.3 mmol/kg/day, and that of mated NZW female rabbits treated with Gadobenate dimeglumine (E7155) caused initial, notable loss of body weight and reduction in food consumption.
Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium.
TLDR
Based on the wide margins of safety demonstrated in different species, particularly in primates, gadobenate dimeglumine can be considered as safe in the range of clinical doses recommended for magnetic resonance imaging.
Comparison of esophageal, tracheal, and mouth occlusion pressure in patients with chronic obstructive pulmonary disease during acute respiratory failure.
TLDR
Because in patients with COPD with upper airways bypassed (tracheostomized or intubated) the changes in esophageal and tracheal pressure during occluded respiratory efforts were similar, it is concluded that the difference between esophagal and mouth occlusion pressure is due to the tissue compliance of the oropharynx.
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
TLDR
Neurotoxicity of monomer or dimer contrast media depends more on chemical structure characteristics other than hydrophilicity than on the physicochemical characteristics of their solutions.
[Assessment of chemoprophylaxis with intermittent tetracycline in chronic bronchitis. A functional follow-up for 3 years (author's transl)].
TLDR
The value of intermittent tetracycline therapy in the reduction of the rate of pulmonary function alteration in patients with chronic obstructive lung disease was reappraisal.
Effects of airway anesthesia on pattern of breathing and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure.
TLDR
It is concluded that activation of airway receptors are involved in the determination of the rapid and shallow breathing observed in patients with COPD during acute respiratory failure, and airway xylocaine anesthesia that worsens arterial blood gases is contraindicated in these patients.
Steady-State Serum T3 Concentrations for 48 Hours Following the Oral Administration of a Single Dose of 3,5,3'-Triiodothyronine Sulfate (T3S).
TLDR
T3S is absorbed following oral administration in hypothyroid humans, and after a single oral dose, T3s is converted to T3 in a dose-dependent manner, resulting in steady-state serum T3 concentrations for 48 hours; T3S may represent a new agent in combination with T4 in the therapy of hypothy thyroidism, if similar conversion of T2S to T2 can be demonstrated in euthyroid patients who are already taking T4.
Toxicological assessment of gadolinium release from contrast media.
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