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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
TLDR
It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain. Expand
HDAC1 Regulates Fear Extinction in Mice
TLDR
It is shown that virus-mediated overexpression of neuronal HDAC1 in the adult mouse hippocampus specifically affects the extinction of contextual fear memories, while other cognitive abilities were unaffected. Expand
DNA methylation changes in plasticity genes accompany the formation and maintenance of memory
TLDR
It is found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression, providing evidence for a molecular framework ofMemory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring. Expand
Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin
TLDR
Melatonin has several distinct advantages as a preserver of organelle structure and function and works via a number of mechanisms to reduce oxidative damage, which assists cells in protecting cells from the degenerative changes normally associated with aging and age-related diseases. Expand
microRNA‐34c is a novel target to treat dementias
TLDR
The data suggest that miR‐34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34ccould be a suitable therapy. Expand
Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus).
TLDR
The implication of the current findings is that consuming cherries could be an important source of dietary melatonin inasmuch as melatonin is readily absorbed when taken orally. Expand
Free Radical‐Mediated Molecular Damage
TLDR
Multiple actions by which melatonin reduces the damaging effects of free radicals and reactive oxygen and nitrogen species make it a potentially useful agent in the treatment of neurological disorders that have oxidative damage as part of their etiological basis. Expand
A hippocampal insulin‐growth factor 2 pathway regulates the extinction of fear memories
TLDR
It is demonstrated that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory, and that fear extinction‐induced IGF2/IGFBP7 signalling promotes the survival of 17–19‐day‐old newborn hippocampal neurons. Expand
Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice
TLDR
It is shown that mice lacking the histone-methyltransferase myeloid/lymphoid or mixed-lineage leukemia 2 (mll2/kmt2b) gene in adult forebrain excitatory neurons display impaired hippocampus-dependent memory function and that KMT2B mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation. Expand
N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
TLDR
AFMK is a naturally occurring molecule with potent free radical scavenging capacity (donating two electrons/molecule) and thus may be a valuable new antioxidant for preventing and treating free radical‐related disorders. Expand
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