S. Burdette

Publications82
h-index20
Citations4,174
Highly Influential Citations35
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Photoisomerization in different classes of azobenzene.
TLDR
This critical review details the studies completed to date on the 3 main classes of azobenzene derivatives and explains the mechanism behind the isomerization mechanism. Expand
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.
TLDR
The X-ray crystal structure of a 2:1 Zn(2+):Zinpyr-1 complex has been solved, and is the first structurally characterized example of a complex of fluorescein substituted with metal binding ligands, making them well-suited for intracellular applications. Expand
A New Cell-Permeable Fluorescent Probe for Zn2+
Although Zn2+ is abundant in eukaryotes and most is tightly bound, pools of chelatable Zn 2+ have been imaged in living cells with concentrations ranging from sub-nM in undifferentiated mammalian… Expand
ZP4, an improved neuronal Zn2+ sensor of the Zinpyr family.
TLDR
A second-generation fluorescent sensor for Zn(2+) from the Zinpyr family, ZP4, has been synthesized and characterized and a 5-fold fluorescent enhancement is observed under simulated physiological conditions corresponding to the binding of the Zn (2+) cation to the sensor, which inhibits a photoinduced electron transfer (PET) quenching pathway. Expand
Meeting of the minds: Metalloneurochemistry
  • S. Burdette, S. Lippard
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 24 March 2003
TLDR
Metalochaperones help to achieve metal ion homeostasis and thus prevent neurological diseases because of metal ion imbalance and much detailed chemical information about these systems has become available recently. Expand
Bright fluorescent chemosensor platforms for imaging endogenous pools of neuronal zinc.
TLDR
It is revealed that careful control of fluorophore pK(a) can minimize proton-induced fluorescence of the apo probes and that electronegative substitution offers a general strategy for tuning PET chemosensors for cellular studies. Expand
Proof for the concerted inversion mechanism in the trans-->cis isomerization of azobenzene using hydrogen bonding to induce isomer locking.
TLDR
These molecules provide important supporting evidence for the spectroscopic and computational studies aimed at elucidating the isomerization mechanism in azobenzene. Expand
Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor
TLDR
It is demonstrated that a new fluorescent stain for zinc can rather selectively and quite vividly label zinc-filled neurons in frozen histologic sections, more sensitive and selective than the existing stain TSQ, and simpler than the Timm-Danscher silver staining techniques. Expand
Photochemical tools for studying metal ion signaling and homeostasis.
TLDR
Photochemical tools such as small molecule and protein-based fluorescent sensors as well as photocaged complexes have provided insight into the homeostasis and signaling mechanisms of Ca, Zn, and Cu, but a comprehensive picture of metal ions in biology will require additional development of these techniques. Expand
Probing nitrobenzhydrol uncaging mechanisms using FerriCast.
TLDR
The FerriCast derivative FC-NDBF was synthesized from 3-methyl-2-nitrodibenzofuran and provides mechanistic insight into the uncaging quantum yields of nitrobenzhydrol-derived ligands. Expand
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