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- Publications
- Influence
Cyclic RGD peptide analogues as antiplatelet antithrombotics.
- P. Barker, S. Bullens, +7 authors M. Lipari
- Chemistry, Medicine
- Journal of medicinal chemistry
- 29 May 1992
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially… Expand
In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
- D. Seshasayee, W. P. Lee, +18 authors F. Martin
- Medicine, Biology
- The Journal of clinical investigation
- 3 December 2007
Thymic stromal lymphopoietin (TSLP) potently induces deregulation of Th2 responses, a hallmark feature of allergic inflammatory diseases such as asthma, atopic dermatitis, and allergic rhinitis.… Expand
A monoclonal antibody that inhibits mouse tissue factor function
- D. Kirchhofer, P. Moran, S. Bullens, F. Peale, S. Bunting
- Chemistry, Medicine
- Journal of thrombosis and haemostasis : JTH
- 1 May 2005
The tissue factor (TF)/factor VIIa (FVIIa) complex not only controls hemostatic processes, but also contributes to thrombosis-related diseases and cancer. Genetic mouse models of human diseases (e.g.… Expand
Effect of Selective or Combined Inhibition of Integrins αIIbβ3 and αvβ3 on Thrombosis and Neointima After Oversized Porcine Coronary Angioplasty
- T. Chico, J. Chamberlain, +13 authors D. Crossman
- Medicine
- 27 February 2001
Background—Thrombosis and neointima formation limit the efficacy of coronary angioplasty (PTCA). Clinical trials have implicated the adhesion molecules integrin αIIbβ3 and integrin αvβ3 in these… Expand
Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.
- C. Eigenbrot, Y. Meng, +7 authors D. Kirchhofer
- Biology, Medicine
- Journal of molecular biology
- 8 August 2003
6A6 is a murine monoclonal antibody raised against the humanized anti-tissue factor antibody D3H44. 6A6 is able to completely neutralize the anticoagulant activity of D3H44 in tissue factor-dependent… Expand
Disulfide locked variants of factor VIIa with a restricted β‐strand conformation have enhanced enzymatic activity
- H. R. Maun, C. Eigenbrot, +4 authors R. Lazarus
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 May 2005
Proteolytic processing of zymogen Factor VII to Factor VIIa (FVIIa) is necessary but not sufficient for maximal proteolytic activity, which requires an additional allosteric influence induced upon… Expand
Effect of selective or combined inhibition of integrins alpha(IIb)beta(3) and alpha(v)beta(3) on thrombosis and neointima after oversized porcine coronary angioplasty.
- T. J. Chico, J. Chamberlain, +13 authors D. Crossman
- Medicine
- Circulation
- 2001
BACKGROUND
Thrombosis and neointima formation limit the efficacy of coronary angioplasty (PTCA). Clinical trials have implicated the adhesion molecules integrin alpha(IIb)beta(3) and integrin… Expand
Intracerebroventricular enzyme replacement therapy with glycosylation-independent lysosomal targeted NAGLU leads to widespread enzymatic activity, reduction of lysosomal storage and of secondary…
- Shih-hsin Kan, Steven Q. Le, +9 authors Patricia I. Dickson
- Chemistry
- 1 February 2014
Treatment for mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome type B) is hampered because recombinant alpha-N-acetylglucosaminidase (NAGLU) contains little/no mannose 6-phosphate. We… Expand
Small cyclic RGD containing peptides as potent inhibitors of platelet aggregation
- John Burnier, P. Barker, +12 authors J. Tom
- Chemistry
- 1992