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Gender-specific and developmental influences on the expression of rat organic anion transporters.
Gender- and age-specific patterns of rat organic anion transporter expression in various tissues are described, indicating that Oat mRNA expression is primarily localized to the kidney, and observed expression patterns may explain some previously recognized age- and gender-dependent toxicities associated with chemical exposure. Expand
Tissue distribution and chemical induction of multiple drug resistance genes in rats.
Rat mdr1 gene expression is not readily increased by microsomal enzyme inducers in rats through coordinate mechanisms with phase I and II drug-metabolizing enzymes, and is thought to function to decrease the absorption of some xenobiotics. Expand
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels.
  • S. Buist, C. Klaassen
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 June 2004
With the exception of a significant species difference in Oat2 expression, many similarities were found between rat and mouse Oat mRNA levels. Expand
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
It is suggested that pursuit of a novel inhibitor leads for antibacterial targets with active-site structural similarity to known human targets will likely be more fruitful than the traditional focus on unique bacterial target space, particularly when structure-based and computational methodologies are applied to ensure bacterial selectivity. Expand
Endocrine regulation of rat organic anion transporters.
It is concluded that androgens, but not GH, are responsible for the Oat1 mRNA gender difference in kidney; the female GH secretion pattern is responsible forThe Oat2 mRNA gender differences in kidney and liver; and both androgens and the femaleGH secretion pattern areresponsible for theOat3 mRNA gender change in liver. Expand
Validation of a rat in vivo [(3)H]M100907 binding assay to determine a translatable measure of 5-HT(2A) receptor occupancy.
The validated [(3)H]M100907 rat in vivo binding assay allows for preclinical measurement of 5-HT(2A) receptor occupancy, providing essential data for understanding the pharmacological profile of novel antipsychotic agents. Expand
Improved enantioselective method for the determination of the enantiomers of reboxetine in plasma by solid-phase extraction, chiral derivatization, and column-switching high-performance liquid
A rapid enantioselective method is described for the quantitation of the reboxetine (R,R)- and (S,S)-enantiomers in plasma utilizing solid-phase extraction, derivatization, normal-phaseExpand
Simple and rapid determination of norethindrone in human plasma by supported liquid extraction and ultra performance liquid chromatography with tandem mass spectrometry.
An ultra performance liquid chromatographic method with tandem mass spectrometric detection (UPLC/MS/MS) for the determination of norethindrone alone in human plasma over the concentration range of 50.0-25000 pg mL(-1) using a sample volume of 0.250 mL was reported for the first time. Expand
Sensitive determination of a new antiarrhythmic agent, trecetilide, in plasma by high-performance liquid chromatography with fluorescence detection.
Two high-performance liquid chromatography (HPLC) methods were developed for the determination of trecetilide in plasma samples. Differing only in the addition of a derivatization step and differentExpand
Evaluation of Pharmacokinetic/Pharmacodynamic Relationships of PD-0162819, a Biotin Carboxylase Inhibitor Representing a New Class of Antibacterial Compounds, Using In Vitro Infection Models
Investigation of the pharmacokinetic/pharmacodynamic relationships of a prototype biotin carboxylase (BC) inhibitor against Haemophilus influenzae 3113 in static concentration time-kill (SCTK) and one-compartment chemostat in vitro infection models concluded that basic PK/PD relationships for PD-0162819 were established using in vitro dynamic systems. Expand