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Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in Neurons
Using unbiased phenotypic screens as an alternative to target-based approaches, NAB identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum–to-Golgi vesicle trafficking. Expand
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient–Derived Neurons
The results of multiple screens in yeast are described that lead to the identification of a potential therapeutic compound to combat the cytotoxic affect of α-synuclein accumulation, and a small molecule identified in a yeast screen, and the ubiquitin ligase Nedd4 it affects, reversed pathologic phenotypes in patient neurons. Expand
A rationally designed universal catalyst for Suzuki-Miyaura coupling processes.
A catalyst system based on a new ligand that meets the above four criteria, has unprecedented scope, reactivity, and stability, uses only commercially available, air-stable components, and is experimentally simple to employ is reported. Expand
Copper-catalyzed coupling of amides and carbamates with vinyl halides.
A general and efficient copper-catalyzed method for the amidation of vinyl bromides and iodides has been developed and the double bond geometry of the vinyl halides was retained under the reaction conditions. Expand
Catalysts for Suzuki-Miyaura coupling processes: scope and studies of the effect of ligand structure.
Structural studies of various 1.Pd complexes are presented along with computational data that help elucidate the efficacy that 1 imparts on Suzuki-Miyaura coupling processes, and a comparison of the reactions is presented that is informative in determining the relative importance of ligand bulk and electron-donating ability in the high activity of catalysts derived from ligands of this type. Expand
Design and Preparation of New Palladium Precatalysts for C-C and C-N Cross-Coupling Reactions.
It was found that replacing the chloride in the previous version of the precatalyst with a mesylate leads to a new class of precatalysts with improved solution stability and that are readily prepared from a wider range of phosphine ligands. Expand
Formation of ArF from LPdAr(F): Catalytic Conversion of Aryl Triflates to Aryl Fluorides
A catalytic process that converts aryl bromides and aryL triflates into the corresponding fluorinated arenes by using simple fluoride salts is developed and it is expected that this method will allow the introduction of fluorine atoms into advanced, highly functionalized intermediates. Expand
Twofold C-H functionalization: palladium-catalyzed ortho arylation of anilides.
The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. The oxidative coupling takes place in the presence of 5-10 mol % ofExpand