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The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.
A polyubiquitin chain anchored to the substrate has been the hallmark of proteasomal recognition. However, the degradation signal appears to be more complex and to contain also a substrate'sExpand
Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.
FAT10 is a ubiquitin-like protein made of two tandem, head-to-tail, ubiquitin domains. It is known to covalently modify proteins in a mechanism similar, though not identical, to that of otherExpand
FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination
The degradation of the ubiquitin-like protein FAT10 requires ubiquitination: degradation was inhibited in cells expressing a nonpolymerizable ubiquitin mutant or harboring a thermolabileExpand
Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle
The mouse int6 gene is a frequent integration site of the mouse mammary tumor virus and INT6 silencing by RNA interference in HeLa cells causes an increased number of cells in the G2/M phases of theExpand
Large-scale analysis of HLA peptides presented by HLA-Cw4
A large number of HLA-Cw4 (Cw *0402) peptides were purified, sequenced, and identified from breast and ovarian carcinoma cell lines. HLA-Cw4 molecules were expressed in these cells as soluble,Expand
Modulation of HIV‐1 Rev protein abundance and activity by polyubiquitination with unconventional Lys‐33 branching
The HIV‐1 Rev protein plays a key role in virus replication by allowing export to the cytoplasm of unspliced or singly‐spliced RNAs. In this report, we investigated whether Rev is modified byExpand
Régulation du facteur de réplication de l'ADN MCM7 par poly-ubiquitinylation : rôles d'Int6 et BRCA1
MCM7, une des sous unites de l’ADN helicase MCM, est poly-ubiquitinylee quand elle est sur la chromatine en replication ou en reparation. Pendant la replication, l’ubiquitinylation degradative deExpand
The fluorescent protein stability assay: an efficient method for monitoring intracellular protein stability.
The stability of intracellular proteins is highly variable, from a few minutes to several hours, and can be tightly regulated to respond to external and internal cellular environment changes. SeveralExpand