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Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals.
TLDR
It is reported that the NO/cGMP-dependent mitochondrial biogenesis is associated with enhanced coupled respiration and content of ATP in U937, L6, and PC12 cells, and that this stimulation isassociated with increased mitochondrial function, resulting in enhanced formation of ATP. Expand
SOX3 is required during the formation of the hypothalamo-pituitary axis
TLDR
How sensitive the pituitary is to subtle developmental defects is shown and how one gene can act at several levels in the hypothalamic-pituitary axis is shown. Expand
Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells.
TLDR
It is shown that pericytes, resident in small vessels of skeletal muscle, contribute to its growth and regeneration during postnatal life and increases significantly during acute injury or in chronically regenerating dystrophic muscle. Expand
Polarization dictates iron handling by inflammatory and alternatively activated macrophages
TLDR
Cytokines that drive macrophage polarization ultimately control iron handling, leading to the differentiation of macrophages into a subset which has a relatively sealed intracellular iron content or into a subsection endowed with the ability to recycle the metal (M2). Expand
Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants
TLDR
In vitro differentiation studies on neural stem cells cultured from embryonic and adult brains of `knockdown' mutants show an in vitro requirement for Sox2 in early differentiating neuronal lineage cells, for maturation and for suppression of alternative lineage markers. Expand
Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy
TLDR
In both models, HCT 1026 significantly ameliorated the morphological, biochemical, and functional phenotype in the absence of secondary effects, efficiently slowing down disease progression and setting the stage for combined therapies with donor or autologous, genetically corrected stem cells. Expand
Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation
TLDR
A model in which the D4Z4 array may play a critical chromatin function as an orchestrator of in cis chromatin loops is proposed, thus suggesting that this repeat might play a role in coordinating gene expression. Expand
Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly
TLDR
The presence of different mutations in cases of severe schizencephaly suggests a requirement of the EMX2 protein for the correct formation of the human cerebral cortex. Expand
Beta catenin-independent activation of MyoD in presomitic mesoderm requires PKC and depends on Pax3 transcriptional activity.
TLDR
It is shown, in explant experiments with presomitic mesoderm, that the expression of another myogenic determination factor, MyoD, depends on non-canonical Wnt signalling, probably emanating from the dorsal ectoderm. Expand
Macrophage Plasticity in Skeletal Muscle Repair
TLDR
The current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types are discussed, with particular attention to the skeletal muscle. Expand
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