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Structure and allosteric inhibition of excitatory amino acid transporter 1
Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of their functions isExpand
Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.
Human Eg5, a mitotic motor of the kinesin superfamily, is involved in the formation and maintenance of the mitotic spindle. The recent discovery of small molecules that inhibit HsEg5 by binding toExpand
Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii
The Antarctic notothenioid Trematomus bernacchii (rock cod) lives at a constant mean temperature of − 1.9 °C. Gastric digestion under these conditions relies on the proteolytic activity of asparticExpand
Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen
Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for understanding the nature of immune responses and designing improved vaccines, therapeutics, and diagnostics.Expand
The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins.
Kinesins are molecular motors that transport cargo along microtubules (MTs). To move forward the motor must attach to the MT in a defined orientation and detach from it in a process that is driven byExpand
Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering theExpand
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
TLDR
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. Expand
Transcriptional Regulation of the nadA Gene in Neisseria meningitidis Impacts the Prediction of Coverage of a Multicomponent Meningococcal Serogroup B Vaccine
ABSTRACT The NadA adhesin is a major component of 4CMenB, a novel vaccine to prevent meningococcus serogroup B (MenB) infection. Under in vitro growth conditions, nadA is repressed by the regulatorExpand
Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5.
An experimental procedure associating both hydrogen/deuterium exchange mass spectrometry (H/D-MS) and mutagenesis was developed to identify the protein-binding region of small inhibitors targetingExpand
The Abl SH2‐kinase linker naturally adopts a conformation competent for SH3 domain binding
The core of the Abelson tyrosine kinase (c‐Abl) is structurally similar to Src‐family kinases where SH3 and SH2 domains pack against the backside of the kinase domain in the down‐regulatedExpand
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