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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
TLDR
The secretome protein enrichment with click sugars (SPECS) method, which allows proteome‐wide identification of shedding substrates and secreted proteins from primary cells, even in the presence of serum proteins, is developed.
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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
TLDR
The novel ADAM10 substrates provide a molecular basis for neuronal network dysfunctions in conditionalADAM10-/- mice and demonstrate a fundamental function of ADAM20 in the brain, according to eLife.
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Chemistry and biology of mycotoxins and related fungal metabolites.
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Organic azides : syntheses and applications
Forewords: Rolf Huisgen, Valery Fokin, and Barry Sharpless. Preface. List of Contributors. Abbreviations. PART 1: SYNTHESIS AND SAFETY. 1 Lab-Scale Synthesis of Azido Compounds: Safety Measures and…
Antibacterial activity of sulfamethoxazole transformation products (TPs): general relevance for sulfonamide TPs modified at the para position.
TLDR
The residual antibacterial activity of 11 transformation products (TPs) of sulfamethoxazole (SMX) was investigated with regard to their in vitro growth and luminescence inhibition on Vibrio fischeri.
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Platinum nanoparticles and their cellular uptake and DNA platination at non-cytotoxic concentrations
TLDR
The observations suggest that DNA strand breaks mediated by metallic Pt-NPs are caused by Pt ions forming during the incubation of cells with these nanoparticles.
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Secretome Analysis Identifies Novel Signal Peptide Peptidase-Like 3 (SPPL3) Substrates and Reveals a Role of SPPL3 in Multiple Golgi Glycosylation Pathways*
TLDR
SPPL3 emerges as a crucial player of Golgi function and the newly identified SPPL3 substrates will be instrumental to investigate the molecular mechanisms underlying the physiological function of SPPL2 in the Golgi network and in vivo.
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Organic azides: an exploding diversity of a unique class of compounds.
TLDR
In this Review, the fundamental characteristics of azide chemistry and current developments are presented and the focus will be placed on cycloadditions (Huisgen reaction), aza ylide chemistry, and the synthesis of heterocycles.
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Xanthones from fungi, lichens, and bacteria: the natural products and their synthesis.
TLDR
The fascinating structural and biological properties of xanthone dimers and heterodimers may excite the synthetic or natural product chemist.
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Synthesis, structure, and characterization of dinuclear copper(I) halide complexes with P^N ligands featuring exciting photoluminescence properties.
TLDR
A series of highly luminescent dinuclear copper(I) complexes has been synthesized in good yields using a modular ligand system of easily accessible diphenylphosphinopyridine-type P^N ligands, revealing a dinuclear complex structure with a butterfly-shaped metal-halide core.
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