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Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome.
TLDR
A key role is supported for germline and somatic variations of A20 in the transformation between autoimmunity and lymphoma in patients with primary Sjögren's syndrome and patients with lymphoma.
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Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rate estimates
Abstract Plasma cystatin C, a new marker of glomerular filtration rate (GFR), was prospectively evaluated in surgical intensive care. Cystatin C was measured (immunonephelometry, Dade-Behring) in 10…
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CXCL13 and CCL11 Serum Levels and Lymphoma and Disease Activity in Primary Sjögren's Syndrome
TLDR
The link between CCL11 and CXCL13 and ectopic GCs, as well as the association between these chemokines and disease activity, in patients with primary Sjögren's syndrome were assessed.
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Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sjögren’s syndrome
TLDR
This study demonstrates major miRNAs deregulation in T and B cells from patients with pSS in two independent cohorts, which might target genes known to be involved in the pathogenesis of pSS.
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Pharmacokinetics of long-term sufentanil infusion for sedation in ICU patients
TLDR
The pharmacokinetic analysis of sufentanil for ICU sedation revealed increased volume of distribution and elimination half-life, which suggest that the rapid reversibility of sedation with sufENTanil is maintained after long duration of infusion.
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Renal hemodynamic and functional effect of PEEP ventilation in human renal transplantations.
TLDR
The results suggest that despite denervation and renal blood flow stability, renal handling of water and salt is perfusion pressure-dependent during PEEP in human renal allograft recipients.
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Overlap between differentially methylated DNA regions in blood B lymphocytes and genetic at-risk loci in primary Sjögren's syndrome
TLDR
Overlap between genes with differentially methylated probes in B lymphocytes and genetic at-risk loci is a new finding highlighting their importance in pSS, demonstrating more important deregulation of DNA methylation patterns in B cells compared with T cells.
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Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort
TLDR
DKK-1 serum levels were increased and SOST levels were decreased among a large cohort of patients with early axial SpA compared to healthy controls and genetic association testing of 10 SNPs encompassing the DKK1 locus failed to demonstrate a significant contribution of genetics to control of DKK- 1 serum levels.
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Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation.
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Germline variation of TNFAIP3 in primary Sjögren's syndrome-associated lymphoma
TLDR
The role of A20 impairment in pSS-associated lymphoma is confirmed, with Subtle germline abnormalities of genes leading to impaired control of NF-kB activation in B cells continuously stimulated by autoimmunity enhance the risk of lymphoma.
View on BMJ
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