New Evidence against Hydroxyl Radicals as Reactive Intermediates in the Thermal and Photochemically Enhanced Fenton Reactions
- S. Bossmann, E. Oliveros, A. Braun
- Chemistry
- 17 April 1998
During the oxidative degradation of 2,4-dimethylaniline (2,4-xylidine) by means of the H2O2/UV method, a series of hydroxylated aromatic amines are formed, this result confirming the role of the…
Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses
- R. Maroto, Yingxin Zhao, A. Brasier
- BiologyJournal of Extracellular Vesicles
- 13 August 2017
Storage destabilizes the surface characteristics, morphological features and protein content of airway exosomes of mouse bronchoalveolar lavage fluid that had been freshly isolated vs. those treated with cold storage or freezing.
High-Temperature Stress Alleviation by Selenium Nanoparticle Treatment in Grain Sorghum
- M. Djanaguiraman, N. Belliraj, S. Bossmann, P. Prasad
- Chemistry, MedicineACS Omega
- 1 March 2018
Se-NPs can protect sorghum plants by enhanced antioxidative defense system under HT stress, and improved the pollen germination percentage, leading to a significantly increased seed yield.
The MspA porin promotes growth and increases antibiotic susceptibility of both Mycobacterium bovis BCG and Mycobacterium tuberculosis.
- C. Mailaender, N. Reiling, H. Engelhardt, S. Bossmann, S. Ehlers, M. Niederweis
- Biology, MedicineMicrobiology
- 1 April 2004
This study provides the first experimental evidence that porins are important for drug susceptibility of M. tuberculosis, and indicates that MspA not only enhanced the efficiency of the porin pathway, but also that of pathways mediating access to large and/or hydrophobic agents.
Copper resistance is essential for virulence of Mycobacterium tuberculosis
- Frank Wolschendorf, David F. Ackart, M. Niederweis
- BiologyProceedings of the National Academy of Sciences
- 4 January 2011
Evidence is provided that Cu is used by the mammalian host to control Mtb infection and that Cu resistance mechanisms are crucial for Mtb virulence, revealing an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy.
A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study
- Sivasai Balivada, R. Rachakatla, D. Troyer
- Biology, MedicineBMC Cancer
- 30 March 2010
It is found that after intravenous administration of micromolar concentrations, these MNPs are capable of causing an anti-tumor effect in a mouse melanoma model after only a short AMF exposure time, a clear improvement to state of the art.
Characterization of Dye-decolorizing Peroxidase (DyP) from Thermomonospora curvata Reveals Unique Catalytic Properties of A-type DyPs*
- Chao Chen, R. Shrestha, Ping Li
- Chemistry, BiologyJournal of Biological Chemistry
- 23 July 2015
Results reveal the unique catalytic property of the A-type DyPs, which will facilitate the development of these enzymes as lignin degraders and allow development of biocatalysts for lign in degradation.
Expression of the ompATb operon accelerates ammonia secretion and adaptation of Mycobacterium tuberculosis to acidic environments
- Houhui Song, Jason T. Huff, M. Niederweis
- BiologyMolecular Microbiology
- 1 May 2011
Results show that the ompATb operon is necessary for rapid ammonia secretion and adaptation of M. tuberculosis to acidic environments in vitro but not in mice, and has multiple mechanisms of resisting phagosomal acidification.
Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus
- M. Haeili, C. Moore, Frank Wolschendorf
- BiologyAntimicrobial Agents and Chemotherapy
- 21 April 2014
A novel high-throughput screening platform specifically developed for the discovery and characterization of compounds with copper-dependent antibacterial properties toward methicillin-resistant Staphylococcus aureus and how one of the identified compounds, glyoxal-bis(N4-methylthiosemicarbazone) (GTSM), exerts its potent strictly copper- dependence on MRSA is reported.
Pulsed magnetic field induced fast drug release from magneto liposomes via ultrasound generation.
- George Podaru, S. Ogden, V. Chikán
- Biology, ChemistryJournal of Physical Chemistry B
- 25 September 2014
An experimental method is developed for the fast release of the liposome' payload without a significant increase in (local) temperatures by using short magnetic pulses to disrupt the lipid bilayer of liposomes loaded with magnetic nanoparticles.
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