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Effects of resistance training on insulin-like growth factor-I and IGF binding proteins.
PURPOSE Our goal was to determine the effects resistance training on circulating IGF-I and on two of its major binding proteins, IGFBP-1 and IGFBP-3. Additional goals were to compare the time courseExpand
Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)
Brain derived neurotrophic factor (BDNF) is postulated to be an important mediator of exercise-induced neuroprotection. We tested the hypothesis that resistance exercise elevates circulating BDNF.Expand
The role of TNF-alpha in insulin resistance.
Insulin resistance is an important component of the metabolic syndrome associated with obesity. Early-stage insulin-resistance and related mild glucose intolerance may be compensated by increasedExpand
Myogenic and proteolytic mRNA expression following blood flow restricted exercise
Aim:  Resistance exercise performed at low loads (20–30% of maximal strength) with blood flow restriction (BFR) acutely increases protein synthesis and induces hypertrophy when performed chronically.Expand
Interventions for sarcopenia and muscle weakness in older people.
  • S. Borst
  • Medicine
  • Age and ageing
  • 1 November 2004
OBJECTIVE three major strategies have been tested for combating the losses in muscle mass and strength that accompany ageing. Those strategies are testosterone replacement for men, growth hormoneExpand
Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
BackgroundPotential cardiovascular (CV) risks of testosterone replacement therapy (TRT) are currently a topic of intense interest. However, no studies have addressed CV risk as a function of theExpand
Neuroendocrine responses to an acute bout of eccentric-enhanced resistance exercise.
PURPOSE The purpose of this study was to compare the total testosterone (TT), bioavailable testosterone (BT), growth hormone (GH), lactate, and ratings of perceived exertion (RPE) responses between aExpand
Early-Phase Neuroendocrine Responses and Strength Adaptations Following Eccentric-Enhanced Resistance Training
Yarrow, JF, Borsa, PA, Borst, SE, Sitren, HS, Stevens, BR, White, LJ. Early-phase neuroendocrine responses and strength adaptations following eccentric-enhanced resistance training. J Strength CondExpand
Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults
Aging is associated with progressive decline of skeletal muscle mass and function. This condition, termed sarcopenia, is associated with several adverse outcomes, including loss of autonomy andExpand
Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.
Testosterone acts directly at androgen receptors and also exerts potent actions following 5α-reduction to dihydrotestosterone (DHT). Finasteride (type II 5α-reductase inhibitor) lowers DHT and isExpand