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Effects of resistance training on insulin-like growth factor-I and IGF binding proteins.
Findings indicate that increased circulating IGF-I may, at least in part, mediate increases in strength that result from resistance training. Expand
Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)
This study is the first to demonstrate that resistance exercise induces a robust, yet transient, elevation of circulating BDNF and that progressive resistance training augments this response; perhaps demonstrating one mechanism through which exercise influences brain health. Expand
The role of TNF-alpha in insulin resistance.
This review will discuss the regulation of insulin responses by TNF-alpha and evidence supporting the hypothesis that over expression of T NF-alpha plays a role in the pathophysiology of insulin resistance and examine the role of fat, especially visceral fat, as an endocrine organ. Expand
Myogenic and proteolytic mRNA expression following blood flow restricted exercise
Resistance exercise performed at low loads with blood flow restriction acutely increases protein synthesis and induces hypertrophy when performed chronically and myogenic and proteolytic mRNA expression is investigated following an acute bout of knee extension exercise. Expand
Interventions for sarcopenia and muscle weakness in older people.
  • S. Borst
  • Medicine
  • Age and ageing
  • 1 November 2004
OBJECTIVE three major strategies have been tested for combating the losses in muscle mass and strength that accompany ageing. Those strategies are testosterone replacement for men, growth hormoneExpand
Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
Differences in the degree to which serum DHT is elevated may underlie the varying CV risk by TRT administration route, as elevated serum dihydrotestosterone has been shown to be associated with CV risk in observational studies. Expand
Neuroendocrine responses to an acute bout of eccentric-enhanced resistance exercise.
TRAD and ECC+ show similar neuroendocrine and differing metabolic responses during the early phase of resistance exercise in untrained, college-age men. Expand
Early-Phase Neuroendocrine Responses and Strength Adaptations Following Eccentric-Enhanced Resistance Training
Evaluating the early-phase muscular performance adaptations to 5 weeks of traditional (TRAD) and eccentric-enhanced (ECC+) progressive resistance training found that TRAD training and ECC+ training appear to result in similar muscular strength adaptations and neuroendocrine responses, while postexercise lactate clearance is enhanced following E CC+ training. Expand
Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults
The most recent evidence regarding age-related changes of the GH/IGF-1 axis and its modulation by several interventions, including ACEIs which might represent a potential novel strategy to delay the onset and impede the progression of sarcopenia are reviewed. Expand
Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial.
It is concluded that a higher-than-replacement TE combined with finasteride significantly increases muscle strength and BMD and reduces body fat without causing prostate enlargement. Expand