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Therapeutic drug monitoring of asparaginase in the ALL‐BFM 2000 protocol between 2000 and 2007
On a voluntary basis therapeutic drug monitoring (TDM) was implemented in the ALL‐BFM 2000 protocol for the three currently used asparaginase (ASNase) preparations (first line: native Escherichia…
Plasma Concentrations of Posaconazole Administered via Nasogastric Tube in Patients in a Surgical Intensive Care Unit
- D. Störzinger, S. Borghorst, T. Hoppe-Tichy
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 14 May 2012
Plasma posaconazole levels in surgical intensive care unit (SICU) patients were measured and a predictive population pharmacokinetics model was tried to develop, showing SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients.
Population Pharmacokinetics of Native Escherichia Coli Asparaginase
- S. Borghorst, R. Pieters, H. Kuehnel, J. Boos, G. Hempel
- Biology, MedicinePediatric hematology and oncology
- 24 February 2012
The model was able to describe asparaginase activity of different dosages in the ALL-BFM protocol and provides further evidence for bioequivalence between ASNase medac™ and a new recombinant asparaginease preparation.
Comparative pharmacokinetic/pharmacodynamic characterisation of a new pegylated recombinant E. colil-asparaginase preparation (MC0609) in Beagle dog
- S. Borghorst, G. Hempel, Sabine Poppenborg, D. Franke, T. König, J. Baumgart
- Biology, MedicineCancer Chemotherapy and Pharmacology
- 17 June 2014
The new pegylated recombinant l-asparaginase preparation MC0609 revealed striking differences in PK/PD properties compared with Oncaspar® in rat and dog.
Population Pharmacokinetic of Native Escherichia Coli Asparaginase.
This PopPK analysis provides the first step in the development of a PopPK model for ASNase and shows face validity of the model could be demonstrated and will be confirmed with an independent dataset.