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CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.
The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memoryExpand
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Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non‐CDKN2A/CDK4 melanoma families
Germline mutations in the major melanoma susceptibility gene CDKN2A explain genetic predisposition in only 10–40% of melanoma‐prone families. In our study we comprehensively characterized 488Expand
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New insights about the potential application of the association of vitamins C (sodium ascorbate) and K3 (menadione) as auxiliary therapy in cancer treatment
Cancer is characterized by cell cycle deregulation, progressive loss of cell differentiation and uncontrolled growth. Since cancer cells are particulary sensitive to oxidative stress, we tookExpand
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No pharmacokinetic interaction between TMC125 (etravirine; ETR) and paroxetine in HIV-negative volunteers
TMC125 is a next-generation NNRTI with potent activity against both wild-type HIV-1 and HIV-1 resistant to current NNRTIs1 Two Phase III trials (DUET-1 and DUET-2) demonstrated significant antiviralExpand
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  • Open Access
CAFE: an R package for the detection of gross chromosomal abnormalities from gene expression microarray data
tl;dr
We present CAFE—Chromosomal Aberration Finder in Expression data—as an R package that analyzes Affymetrix *.CEL files and comes with flexible plotting functions, easing visualization of chromosomal abnormalities. Expand
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  • Open Access
BIOPET: Towards Scalable, Maintainable, User-Friendly, Robust and Flexible NGS Data Analysis Pipelines
tl;dr
We have developed a GATK-Queue based open source pipeline framework – BIOPET (Bioinformatics Pipeline Execution Toolkit). Expand
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  • Open Access
Association between a 46-SNP Polygenic Risk Score and melanoma risk in Dutch patients with familial melanoma.
BACKGROUND Familial clustering of melanoma suggests a shared genetic predisposition among family members, but only 10%-40% of familial cases carry a pathogenic variant in a known high-risk melanomaExpand
University of Groningen Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non-CDKN2A/CDK4 melanoma families. Potjer,
Citation for published version (APA): Potjer, T. P., Bollen, S., Grimbergen, A. J. E. M., van Doorn, R., Gruis, N. A., Asperen, C. J., ... Dutch Working Group for Clinical Oncogenetics (2019).Expand
COREC: the end of trainee-driven clinical research?
Since 1 March 2004 anyone who wishes to set up clinical trials in the United Kingdom has to go through an extensive application process to gain ethical approval. The Central Office for ResearchExpand
Repurposing of Diagnostic Whole Exome Sequencing Data of 1,583 Individuals for Clinical Pharmacogenetics
For ~ 80 drugs, widely recognized pharmacogenetics dosing guidelines are available. However, the use of these guidelines in clinical practice remains limited as only a fraction of patients isExpand