• Publications
  • Influence
Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2.
Allergens are diverse proteins from mammals, birds, arthropods, plants, and fungi. Allergens associated with asthma (asthmagens) share a common protease activity that may directly impact respiratoryExpand
  • 98
  • 7
  • PDF
Modulation of pulmonary alveolar type II cell phenotype and communication by extracellular matrix and KGF.
The alveolar epithelium consists of two cell types, alveolar type I (AT1) and alveolar type II (AT2) cells. We have recently shown that 7-day-old cultures of AT2 cells grown on a type IExpand
  • 74
  • 4
  • PDF
Cell-cell communication in heterocellular cultures of alveolar epithelial cells.
The mammalian alveolar epithelium is composed of alveolar type I (AT1) and alveolar type II (AT2) cells that together coordinate tissue function. We used a heterocellular culture model of AT1 and AT2Expand
  • 59
  • 3
The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain
Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin andExpand
  • 62
  • 3
  • PDF
Site-Specific Connexin Phosphorylation Is Associated with Reduced Heterocellular Communication between Smooth Muscle and Endothelium
Background/Aims: Myoendothelial junctions (MEJs) represent a specialized signaling domain between vascular smooth muscle cells (VSMC) and endothelial cells (EC). The functional consequences ofExpand
  • 36
  • 3
Trichloroethylene disrupts cardiac gene expression and calcium homeostasis in rat myocytes.
We have been investigating the molecular mechanisms by which trichloroethylene (TCE) might induce cardiac malformations in the embryonic heart. Previous results indicated that TCE disruptedExpand
  • 29
  • 2
  • PDF
The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo
Proteinase‐activated receptor‐2 (PAR2) is a GPCR linked to diverse pathologies, including acute and chronic pain. PAR2 is one of the four PARs that are activated by proteolytic cleavage of theExpand
  • 23
  • 2
Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine
BackgroundThe potential for adverse respiratory effects following exposure to electronic (e-) cigarette liquid (e-liquid) flavorings remains largely unexplored. Given the multitude of flavorExpand
  • 71
  • 1
Cell-cell interactions in regulating lung function.
Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elementsExpand
  • 48
  • 1
  • PDF
Cytotoxicity and physicochemical properties of hafnium oxide nanoparticles.
Nano-sized hafnium oxide (HfO(2)) particles are being considered for applications within the semiconductor industry. However, little is known about their cytotoxicity. The objective of this work wasExpand
  • 28
  • 1