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Intercellular propagation of calcium waves mediated by inositol trisphosphate.
It is demonstrated that the release ofCa2+ by IP3 is necessary for the propagation of intercellular Ca2+ waves and suggested that IP3 moves through gap junctions to communicate inter cellular Ca 2+ waves.
Mechanisms and function of intercellular calcium signaling
The function of intercellular Ca2+ waves may be the coordination of cooperative cellular responses to local stimuli, and may represent a general mechanism by which cells communicate.
Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication.
Connexin mimetic peptides that correspond to short specific sequences in the two extracellular loops of connexins are a class of benign, specific and reversible inhibitors of gap-junctional communication that have been studied recently in a broad range of cells, tissues and organs.
Trout sperm swimming patterns and role of intracellular Ca
Differences in swimming patterns upon activation by high Ca++ concentration suggest additional effects of Ca++ on regulating swimming patterns, and the fluorescent Ca++ indicator Fluo-3 was used to measure changes in intracellular Ca ++ concentration upon activation.
Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells.
  • S. Boitano, W. H. Evans
  • Biology, Medicine
    American journal of physiology. Lung cellular and…
  • 1 October 2000
It is concluded that connexin mimetic peptides are effective and reversible inhibitors of gap junctional communication of physiologically significant molecules that underlie Ca(2+) wave propagation in tracheal epithelial cells and a potential mechanism for the mode of action is proposed.
Intercellular calcium signaling induced by extracellular adenosine 5'-triphosphate and mechanical stimulation in airway epithelial cells.
It is concluded that the intercellular Ca2+ waves elicited by mechanical stimulation are not the result of ATP or another compound released from the stimulated cell, diffusing through the extracellular fluid, but rather the movement of inositol trisphosphate through gap junctions.
A role for phospholipase C activity but not ryanodine receptors in the initiation and propagation of intercellular calcium waves.
The hypotheses that: (1) an elevation of [IP3]i is required to initiate intercellular Ca2+ waves; (2) mechanical stimulation activates PLC; and (3) Ca 2+ wave propagation in airway epithelial cells involves Ca2- release from intracellular stores primarily via IP3 receptors are supported are supported.
Membrane hyperpolarization activates trout sperm without an increase in intracellular pH.
A model where membrane hyperpolarization is the trigger that initiates the cascade of events leading to trout sperm activation is proposed, where changes in intracellular pH do not regulate trout sperm motility.
Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2.
It is demonstrated that A. alternata proteases act through PAR(2) to induce rapid increases in human airway epithelial [Ca(2+)](i) in vitro and cell recruitment in vivo, likely critical early steps in the development of allergic asthma.
A role for Ca(2+)-conducting ion channels in mechanically-induced signal transduction of airway epithelial cells.
Mechanical stimulation of a single cell in a cultured monolayer of airway epithelial cells initiates an intercellularly communicated increase in intracellular Ca2+ concentration ([Ca2+]i) that