Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.
- S. Boissier, M. Ferreras, P. Clézardin
- Biology, ChemistryCancer Research
- 1 June 2000
Evidence that BP pretreatment of breast and prostate carcinoma cells inhibited tumor cell invasion in a dose-dependent manner is provided and BPs may be useful agents for the prophylactic treatment of patients with cancers that are known to preferentially metastasize to bone is suggested.
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.
- P. Fournier, S. Boissier, P. Clézardin
- Biology, MedicineCancer Research
- 15 November 2002
BPs have in vivo antiangiogenic properties, which could be of relevance to improve therapy and prevention of bone metastasis, and extend the potential clinical use of BPs to patients with early prostate cancer.
Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.
- S. Boissier, S. Magnetto, P. Clézardin
- Biology, MedicineCancer Research
- 15 September 1997
Evidence is provided for a direct cellular effect of BP in preventing tumor cell adhesion to bone, suggesting that BPs may be useful agents for the prophylactic treatment of patients with cancer that is known to preferentially metastasize to bone.
In vitro and in vivo antitumor effects of bisphosphonates.
- P. Clézardin, P. Fournier, S. Boissier, O. Peyruchaud
- Biology, ChemistryCurrent Medicinal Chemistry
- 2003
In vitro preclinical evidence that bisphosphonates can act on tumor cells: they inhibit tumor cell adhesion to mineralized bone as well as tumor cell invasion and proliferation, and induce also tumor cell apoptosis and stimulate gammadelta T cell cytotoxicity against tumor cells is presented.
Human breast tumors override the antiangiogenic effect of stromal thrombospondin‐1 in vivo
- A. Fontana, S. Filleur, P. Clézardin
- Medicine, BiologyInternational Journal of Cancer
- 20 September 2005
It is demonstrated here that stromal TSP‐1 delayed human MDA‐MB‐231/B02 breast tumor growth, but this delay was associated with an increased vascular endothelial growth factor (VEGF) expression in tumor cells themselves, leading to a tumor growth rate comparable to that of tumors whose fibroblasts did not overproduce T SP‐1.
Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone
- S. Magnetto, S. Boissier, P. Delmas, P. Clézardin
- Biology, MedicineInternational Journal of Cancer
- 8 October 1999
The findings raise the interesting possibility that the combination of bisphosphonates and taxoids may be useful for the treatment of patients with cancer types that are known to metastasize preferentially to bone.
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies
- J. Collombet, H. Faure‐Vigny, G. Stepien
- Biology, MedicineMolecular and Cellular Biochemistry
- 1 March 1997
In cultured muscle cells from patients with mtDNA mutations, the percentage of mutated mtDNA was low as compared with those determined in the corresponding skeletal muscle biopsy, and an undetermined transcriptional event should be involved to account for such abnormal transcript patterns.