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Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.
The molecular mechanisms by which tumor cells metastasize to bone are likely to involve invasion, cell adhesion to bone, and the release of soluble mediators from tumor cells that stimulateExpand
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.
Bisphosphonates (BPs) are used currently in the treatment of patients with bone metastases because these compounds inhibit bone resorption. We examined here the effects of BPs on inhibition ofExpand
Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.
The molecular mechanisms by which tumor cells induce osteolytic metastases are likely to involve tumor cell adhesion to bone as well as the release of soluble mediators from tumor cells thatExpand
In vitro and in vivo antitumor effects of bisphosphonates.
Bisphosphonates are powerful inhibitors of osteoclast-mediated bone resorption. They are currently used in the palliative treatment of bone metastases. However, bisphosphonates do not only act onExpand
Human breast tumors override the antiangiogenic effect of stromal thrombospondin‐1 in vivo
The antiangiogenic extracellular matrix protein thrombospondin‐1 (TSP‐1) inhibits tumor growth and metastasis in animals. However, the clinical relevance of such findings are equivocal as increasedExpand
Additive antitumor activities of taxoids in combination with the bisphosphonate ibandronate against invasion and adhesion of human breast carcinoma cells to bone
A very common metastatic site for breast carcinoma is bone. Metastatic breast carcinoma cells stimulate osteoclast‐mediated bone resorption leading to osteolysis. Bisphosphonates are powerfulExpand
Expression of oxidative phosphorylation genes in muscle cell cultures from patients with mitochondrial myopathies
The expression of several mitochondrial and nuclear genes involved in ATP production was examined in cells cultured from muscle biopsies of patients harboring mitochondrial pathologies. TheExpand