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A competitive kinetic model of nucleic acid surface hybridization in the presence of point mutants.
The results presented suggest that it may be more appropriate to consider collective rather than quasi-independent interaction of targets in multicomponent systems. Expand
Biosensing based upon molecular confinement in metallic nanocavity arrays
We study enhancement of fluorescence of molecular species bound within metallic nanocavities. These nanostructures possess a number of desirable properties for real-time microarrays, such asExpand
Crucial role of the adhesion layer on the plasmonic fluorescence enhancement.
This work presents the first experimental report of the strong dependence of the plasmonic enhancement of single-molecule fluorescence on the nature of the adhesion layer and demonstrates the largest enhancement factor reported to date (25×) by using a TiO(2)Adhesion layer. Expand
Nanoaperture-enhanced fluorescence : Towards higher detection rates with plasmonic metals
A bare nanometric aperture milled in a metallic film forms a simple nanophotonic device that can strongly enhance the optical properties of nearby emitters such as fluorescent molecules. In thisExpand
Nonlinearity enhancement in finite coupled-resonator slow-light waveguides.
It is shown that the group index strongly depends on the number of cavities in the system, especially for operation at the center frequency, and the nonlinear phase sensitivity shows an enhancement proportional to the square of the groupIndex. Expand
Kinetics of multiplex hybridization: mechanisms and implications.
It is suggested here that a simplified three-component kinetic model may present a sufficient approximation to describe the general case of DNA sensing in a complex sample milieu and it is shown that, by analyzing the real-time hybridization kinetics of a nontarget species, it can perform quantitative analysis of unlabeled targets of interest within a broad dynamic range of concentrations. Expand
Logic synthesis for integrated optics
This work presents design and synthesis methodologies for implementing digital logic using conventional integrated optical components, specifically optical cross-bar routing devices based on Mach-Zehnder Interferometry, and utilizes the unique advantages of these optical devices, while also addressing the limitations of the technology. Expand
Characterization of a 3D optrode array for infrared neural stimulation
The Utah Slant Optrode Array is characterizes as a means to deliver infrared light deep into tissue and output power varied with the optrode length/taper such that longer and less tapered optrodes exhibited higher light transmission efficiency. Expand
Crossing-Aware Channel Routing for Integrated Optics
Two distinct channel routing techniques are presented: a new channel routers based on net sorting and utilizing non-Manhattan routing grids and a router based on crossing-aware graph-constrained track assignment that also exploits waveguide curves to improve track utilization. Expand
Exact field solution to guided wave propagation in lossy thin films.
The full-field solution for electromagnetic wave propagation in a symmetric dielectric slab with finite absorption is derived and an approximate solution for the longitudinal attenuation coefficient αz is derived from geometric optics and shows excellent agreement with the exact value. Expand