• Publications
  • Influence
Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission
TLDR
Analysis of protein structure stability of surface glycoprotein mutants indicated viability of specific variants and are more prone to be temporally and spatially distributed across the globe, while empirical analysis of other proteins indicated existence of important functional implications of several variants. Expand
Characterizations of SARS-CoV-2 mutational profile, spike protein stability and viral transmission
TLDR
Analysis of protein structure stability of surface glycoprotein mutants indicated the viability of specific variants and are more prone to be temporally and spatially distributed across the globe. Expand
Production and recovery of recombinant propapain with high yield.
TLDR
This is a simple and efficient expression and purification procedure to obtain a yield of active papain, which is the highest reported so far for any recombinant plant cysteine protease. Expand
Functional properties of soybean nodulin 26 from a comparative three‐dimensional model
  • S. Biswas
  • Chemistry, Medicine
  • FEBS letters
  • 30 January 2004
TLDR
Structural features of the nodulin 26 channel protein indicate a selectivity filter that differs from those of the known structures of Escherichia coli glycerol facilitator and mammalian aquaporin 1. Expand
Protein interactions of Merocyanine 540: spectroscopic and crystallographic studies with lysozyme as a model protein.
TLDR
X-ray crystallographic structure of the complex shows that MC 540 adopts two conformations, cis and trans, while it binds to lysozyme, and the binding forces as hydrogen bonding/van der Waal's and ionic/hydrophobic respectively. Expand
Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria.
TLDR
In this enzyme, the nature of the S2 subsite is similar to that of papain, but at the S3 subsite, Ala67 replaces an aromatic residue, and has the effect of eliminating sufficient hydrophobic interactions required for S3-P3 stabilization, which provides the possible explanation for the lower activity of ervatamin C toward the small substrate/inhibitor. Expand
Structural insights into the substrate specificity and activity of ervatamins, the papain‐like cysteine proteases from a tropical plant, Ervatamia coronaria
TLDR
The studies indicate a higher enzymatic activity of ervatamin‐A, which has been subsequently explained at the molecular level from the three‐dimensional structure of the enzyme and in the context of its helix polarizibility and active site plasticity. Expand
Proposed amino acid sequence and the 1.63 Å X‐ray crystal structure of a plant cysteine protease, ervatamin B: Some insights into the structural basis of its stability and substrate specificity
TLDR
The crystal structure of a cysteine protease ervatamin B, isolated from the medicinal plant Ervatamia coronaria, has been determined at 1.63 Å and a few natural substitutions of conserved amino acid residues at the interdomain cleft of erv atamin B are expected to increase the stability of the protein. Expand
Improving thermostability of papain through structure-based protein engineering.
TLDR
The structure-based rational design approach to improve the thermostability of papain, without perturbing its enzymatic activity, by introducing three mutations at its interdomain region indicates highest stability for the triple mutant based on higher number of interdomain H-bonds/salt-bridges, less interdomain flexibility and lower stability free-energy compared to the WT. Expand
An apyrase from Mimosa pudica contains N5,N10-methenyl tetrahydrofolate and is stimulated by light.
TLDR
An apyrase implicated in the response of Mimosa pudica to stimuli, such as touch, has been cloned, sequenced and expressed in Escherichia coli and it was observed that a chromophore is associated with it, having absorption in the ultraviolet-A/blue region of the spectrum. Expand
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