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Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents.
TLDR
TAK-003 was efficacious against symptomatic dengue in countries in which the disease is endemic and the incidence of serious adverse events was similar in the vaccine group and placebo group. Expand
Efficacy of a tetravalent dengue vaccine in healthy children aged 4–16 years: a randomised, placebo-controlled, phase 3 trial
TLDR
TAK-003 was well tolerated and efficacious against symptomatic dengue in children regardless of serostatus before immunisation, warranting continued follow-up to assess longer-term vaccine performance. Expand
Longterm efficacy of topical nonsteroidal antiinflammatory drugs in knee osteoarthritis: metaanalysis of randomized placebo controlled clinical trials.
TLDR
Topical NSAID are effective for pain relief in knee OA for a longer duration; however, this may not hold true for all the preparations. Expand
Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study
TLDR
Everolimus improved some lung function measures and reduced serum biomarkers in patients with LAM and side effects were generally consistent with known toxicities of mTOR inhibitors, although some were severe. Expand
A single-dose, randomized, open-label, two-period crossover bioequivalence study of a fixed-dose pediatric combination of lamivudine 40-mg, nevirapine 70-mg, and stavudine 10-mg tablet for oral
TLDR
The FDC pediatric formulation of lamivudine, nevirapine, and stavudine was bioequivalent to the individual liquid formulations in these fasting, healthy Indian men. Expand
Effect of oral siponimod (BAF312) on the pharmacokinetics and pharmacodynamics of a monophasic oral contraceptive in healthy female subjects.
OBJECTIVE To evaluate the effects of siponimod (BAF312) on the pharmacokinetics (PK) and pharmacodynamics (PD) of a monophasic oral contraceptive (OC). MATERIALS AND METHODS This was a phase 1,Expand
Relative bioavailability of diclofenac potassium from softgel capsule versus powder for oral solution and immediate‐release tablet formulation
TLDR
The peak plasma concentration of diclofenac from the new softgel capsule was 67% higher than the existing tablet formulation, whereas it was 15% lower in comparison with the oral solution formulation. Expand
Efficient deposition and sustained lung concentrations of NVA237 after inhalation via the Breezhaler® device in man
TLDR
NVA237 inhaled via the Breezhaler® device is efficiently deposited and absorbed in the lungs and the terminal half life of NVA237 is much longer after inhalation than after i.v. or oral dosing which points to sustained lung concentrations of Nva237 following inhalation. Expand
Pharmacokinetic and pharmacodynamic interaction of siponimod (BAF312) and propranolol in healthy subjects.
TLDR
Coadministration of siponimod and propranolol was well tolerated and Bradyarrhythmic effects were less pronounced when proprolol was added to sip onimod steady-state therapy compared with siponIMod addition to propr ethanol. Expand
Bioavailability of valsartan oral dosage forms
TLDR
Results indicate that both rate and extent of absorption of valsartan are higher in the two liquid dosage forms (extemporaneous suspension and solution formulations) relative to the solid oral dosage form (tablet formulation). Expand
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