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Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV
MOTIVATION The ability to detect copy-number variation (CNV) and loss of heterozygosity (LOH) from exome sequencing data extends the utility of this powerful approach that has mainly been used forExpand
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Immunohistochemical characteristics of melanoma
Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas fromExpand
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The Role of Thymus-Expressed Chemokine and Its Receptor CCR9 on Lymphocytes in the Regional Specialization of the Mucosal Immune System1
Chemokines play an important role in the migration of leukocytes at sites of inflammation, and some constitutively expressed chemokines may direct lymphocyte trafficking within lymphoid organs andExpand
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Outcome of cytomegalovirus infections in patients with inflammatory bowel disease
OBJECTIVE:The aim of this study was to determine the outcome of cytomegalovirus (CMV) infections complicating the course of inflammatory bowel disease (IBD).METHODS:The records and clinical coursesExpand
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CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
BACKGROUND & AIMS Thymus-expressed chemokine (TECK) or CCL25) is selectively expressed in the small bowel (SB), where lamina propria lymphocytes (LPL) and intraepithelial leukocyte expressing theExpand
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Defining the origins of Ras/p53-mediated squamous cell carcinoma
The precise identity of cancer cells of origin and the molecular events of tumor initiation in epidermal squamous cell carcinoma (SCC) are unknown. Here we show that malignancy potential is relatedExpand
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Mice with combined disruption of Gpx1 and Gpx2 genes have colitis.
Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI), encoded by Gpx1 and Gpx2, provide most GPX activity in GI epithelium. Although homozygous mice deficient inExpand
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Ossifying Fibromyxoid Tumor of Soft Parts: A Clinicopathologic, Proteomic, and Genomic Study
Ossifying fibromyxoid tumor (OFMTs) of soft parts is a rare soft tissue and bone tumor of borderline malignancy displaying an uncertain line of differentiation. The existence of fully malignant OFMTExpand
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Malignant Melanotic Schwannian Tumor: A Clinicopathologic, Immunohistochemical, and Gene Expression Profiling Study of 40 Cases, With a Proposal for the Reclassification of “Melanotic Schwannoma”
Melanotic schwannomas (MSs), variably associated with the Carney complex, are rare tumors that usually involve spinal nerve roots but may occur in other locations. Clinicopathologic evaluation poorlyExpand
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Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup.
BACKGROUND & AIMS Antineutrophil cytoplasmic antibodies (ANCA) have been consistently detected in a subgroup of patients with Crohn's disease (CD). This study was designed to determine whether serumExpand
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