• Publications
  • Influence
Arcanobacterium pyogenes: molecular pathogenesis of an animal opportunist
Arcanobacterium pyogenes is a commensal and an opportunistic pathogen of economically important livestock, causing diseases as diverse as mastitis, liver abscessation and pneumonia. This organismExpand
  • 157
  • 28
Prevalence of cpb2, encoding beta2 toxin, in Clostridium perfringens field isolates: correlation of genotype with phenotype.
Beta2 toxin, encoded by the cpb2 gene, has been implicated in the pathogenesis of porcine, equine and bovine enteritis by type A Clostridium perfringens. By incorporating primers to cpb2 into aExpand
  • 187
  • 25
Atypical cpb2 Genes, Encoding Beta2-Toxin in Clostridium perfringens Isolates of Nonporcine Origin
ABSTRACT Beta2-toxin, encoded by cpb2, is implicated in the pathogenesis of Clostridium perfringens enteritis. However, cpb2 genes from nonporcine C. perfringens isolates were not always expressed,Expand
  • 84
  • 23
  • PDF
Characterization of Campylobacter jejuni Biofilms under Defined Growth Conditions
ABSTRACT Campylobacter jejuni is a major cause of human diarrheal disease in many industrialized countries and is a source of public health and economic burden. C. jejuni, present as normal flora inExpand
  • 190
  • 19
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Clostridium perfringens is a Gram-positive, anaerobic spore-forming bacterium commonly found in soil, sediments, and the human gastrointestinal tract. C. perfringens is responsible for a wideExpand
  • 283
  • 16
Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis.
Four genes, fagA, B, C and D, encoding products with 32-47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the CorynebacteriumExpand
  • 60
  • 9
Prevalence of Salmonella spp. in Oysters in the United States
ABSTRACT Food-borne diseases such as salmonellosis can be attributed, in part, to the consumption of raw oysters. To determine the prevalence of Salmonella spp. in oysters, oysters harvested from 36Expand
  • 138
  • 8
  • PDF
An Arcanobacterium (Actinomyces) pyogenes mutant deficient in production of the pore-forming cytolysin pyolysin has reduced virulence.
Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins. Insertional inactivation of theExpand
  • 49
  • 8
  • PDF
Thiol-activated cytolysins: structure, function and role in pathogenesis.
Members of the thiol-activated family of cytolysins are involved in the mechanism of pathogenesis of a number of Gram-positive species. While they are pore-forming toxins, their major pathogenicExpand
  • 118
  • 7
Spider and Bacterial Sphingomyelinases D Target Cellular Lysophosphatidic Acid Receptors by Hydrolyzing Lysophosphatidylcholine*
Bites by Loxosceles spiders can produce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, hemolysis, and persistent inflammation. The causative factor is aExpand
  • 130
  • 6