Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro and how closely hepatoma, stem cell and iPS cell–derived hepatocyte-like-cells resemble real hepatocytes.
A deterministic map of Waddington's epigenetic landscape for cell fate specification
This quantitative map of the epigenetic landscape underlying cell fate choice provides mechanistic insights into the "forces" that direct cellular differentiation in the context of physiological development, as well as during artificially induced cell lineage reprogramming.
Modulation of Cyclophosphamide-Induced Cellular Toxicity by Diphenylmethyl Selenocyanate In Vivo, an Enzymatic Study
- Pramita Chakraborty, U. H. Sk, N. Murmu, J. Das, S. Pal, S. Bhattacharya
- Chemistry, Biology
- 28 February 2009
Diphenylmethyl selenocyanate has the potential to prevent CP-induced cellular toxicity, and this compound has been evaluated for its protective potential against CP- induced toxicity in Swiss albino mice.
Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways
Moving from current practice to the NRC vision would require using prototype toxicity pathways to develop case studies showing the new vision in action, and how the proposed strategy for toxicity testing might be applied to the toxicity pathways associated with DNA damage and repair.
Prevention of doxorubicin (DOX)-induced genotoxicity and cardiotoxicity: Effect of plant derived small molecule indole-3-carbinol (I3C) on oxidative stress and inflammation.
Ultrasensitive response motifs: basic amplifiers in molecular signalling networks
Serving as basic signal amplifiers, ultrasensitive response motifs (URMs) are essential for molecular circuits to produce complex nonlinear dynamics, including multistability, robust adaptation and oscillation.
Inhibition of DMBA/croton oil-induced two-stage mouse skin carcinogenesis by diphenylmethyl selenocyanate
- R. Das, S. Ghosh, A. Sengupta, S. Das, S. Bhattacharya
- Chemistry, BiologyEuropean Journal of Cancer Prevention
- 1 October 2004
The antioxidative roles of a synthetic organoselenium compound, diphenylmethyl selenocyanate, were evaluated against 7,12-dimethylbenz(a)anthracene (DMBA)/croton oil-induced two-stage mouse skin carcinogenesis model and found to reduce papilloma formation during chemically induced carcinogenesis.
Fractal dimensions of silica gels generated using reactive molecular dynamics simulations.
It is determined that the effect of supercritical drying on the fractal nature of condensed silica gels is not appreciable.
Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates.