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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8. Expand
A TRP Channel that Senses Cold Stimuli and Menthol
This work describes the cloning and characterization of TRPM8, a distant relative of VR1 that is specifically expressed in a subset of pain- and temperature-sensing neurons and implicates an expanded role for this family of ion channels in somatic sensory detection. Expand
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
- D. Andersson, C. Gentry, S. Moss, S. Bevan
- Chemistry, Medicine
- The Journal of Neuroscience
- 5 March 2008
Electrophysiological methods and measurements of intracellular calcium concentration show that TRPA1 is activated by several classes of endogenous thiol-reactive molecules and demonstrate that multiple agents produced during episodes of oxidative stress can activate TRpa1 expressed in sensory neurons. Expand
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
The cloning and characterization of a novel thermosensitive TRP channel, TRPV3, which is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures is described. Expand
PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.
It is proposed that the PGE2‐mediated increase in excitability in sensory neurones may be due, at least in part, to the cAMP‐protein kinase A‐dependent modulation of the tetrodotoxin‐resistant sodium channel. Expand
Pain related behaviour in two models of osteoarthritis in the rat knee
An analysis of pain related behaviours in two models of OA in the rat: partial medial meniscectomy and iodoacetate injection provides a basis for studies on the mechanisms of pain in OA, and for development of novel therapeutic analgesics. Expand
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
The expression of TRPA 1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA2 may have a role in sensory transduction in this organ. Expand
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin
- S. Bevan, S. Hothi, +5 authors J. Yeats
- Chemistry, Medicine
- British journal of pharmacology
- 1 October 1992
The present study shows the capsazepine acts as a competitive antagonist of capsaicin, with significant effects on the efflux of 86Rb+ from cultured DRG neurones evoked either by depolarization with high (50 mm) K+ solutions or by acidification of the external medium to pH 5.6. Expand
Protons activate a cation conductance in a sub‐population of rat dorsal root ganglion neurones.
No proton‐activated fluxes of either [14C]guanidinium or 86Rb+ ions were observed in cultures of DRG neurones that had been treated with high concentrations of Capsaicin to kill the capsaicin‐sensitive peripheral sensory neurones. Expand
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
- A. Clark, P. Yip, +9 authors M. Malcangio
- Proceedings of the National Academy of Sciences
- 19 June 2007
It is suggested that under conditions of increased nociception, microglial CatS is responsible for the liberation of neuronal FKN, which stimulates p38 MAPK phosphorylation in microglia, thereby activating neurons via the release of pronociceptive mediators. Expand