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Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials.
- C. Granchi, S. Bertini, M. Macchia, F. Minutolo
- Biology, MedicineCurrent medicinal chemistry
- 28 February 2010
An overview of the LDH inhibitors that have been developed up to now, an analysis of their possible isoform-selectivity, and their therapeutic potentials are provided.
Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach
- M. Adami, P. Frati, +5 authors G. Soldani
- Chemistry, MedicineBritish journal of pharmacology
- 1 April 2002
The results indicate that gastric antisecretory effects of cannabinoids in the rat are mediated by suppression of vagal drive to the stomach through activation of CB1 receptors, located on pre‐ and postganglionic cholinergic pathways.
Pharmacokinetics of enrofloxacin in the seabass (Dicentrarchus labrax)
Abstract The plasma kinetics and tissue distribution of enrofloxacin (EF) were investigated in the seabass (Dicentrarchus labrax) after administration by oral gavage and by bath. Plasma and tissue…
Purification, Enzymatic Characterization, and Inhibition of theZ-Farnesyl Diphosphate Synthase from Mycobacterium tuberculosis *
- M. C. Schulbach, S. Mahapatra, +6 authors D. Crick
- Chemistry, MedicineThe Journal of Biological Chemistry
- 13 April 2001
It is shown that open reading frame Rv1086 of the Mycobacterium tuberculosis H37Rv genome sequence encodes a unique isoprenyl diphosphate synthase, which has a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, arabinan, linker unit galactan, and lipoarabinomannan.
Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.
- A. Rossello, S. Bertini, +5 authors B. Macchia
- Chemistry, MedicineJournal of medicinal chemistry
- 26 September 2002
The results of this work seem to confirm that it is possible to reverse the atomic sequence of the methyleneaminoxy group, C=N-O, of 6, obtaining new imidazoles possessing good antifungal properties.
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells
Cell viability experiments carried out by WST-1 assay demonstrated that oleocanthal had a remarkable and selective activity for human melanoma cells versus normal dermal fibroblasts with IC50s in the low micromolar range of concentrations, which may suggest that extra virgin olive oil phenolic extract enriched in oleOCanthal deserves further investigation in skin cancer.
Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the beagle dog.
- L. Intorre, G. Mengozzi, M. Maccheroni, S. Bertini, G. Soldani
- Chemistry, MedicineJournal of veterinary pharmacology and…
- 1 October 1995
The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophyLLine dosage.
The Plasma Kinetics and Tissue Distribution of Enrofloxacin and its Metabolite Ciprofloxacin in the Muscovy Duck
- L. Intorre, G. Mengozzi, S. Bertini, M. Bagliacca, E. Luchetti, G. Soldani
- MedicineVeterinary Research Communications
It was concluded that a dose of 10 mg/kg per day provides serum and tissue concentrations sufficiently high to be effective in the control of many infectious diseases of ducks.
Oral single-dose pharmacokinetics of thiamphenicol in the sea-bass (Dicentrarchus labrax).
Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and intramuscular administrations in sheep.
- G. Mengozzi, L. Intorre, S. Bertini, G. Soldani
- Chemistry, MedicineAmerican journal of veterinary research
- 1 July 1996
The large volume of distribution indicates that enrofloxacin is widely distributed in the body of sheep, and suggests that, in this species, the antimicrobial activity of enroFloxacIn could be attributable, at least in part, to its main metabolite ciprofl oxacin.