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Simalikalactone D is responsible for the antimalarial properties of an Amazonian traditional remedy made with Quassia amara L. (Simaroubaceae).
TLDR
A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC(50) value of 10nM against FcB1 Plasmodium falciparum chloroquine resistant strain in vitro and in vivo, and these findings confirm the traditional use of this herbal tea. Expand
Evaluation of French Guiana traditional antimalarial remedies.
TLDR
It is shown that a traditional preventive remedy, made from Geissospermum argenteum bark macerated in rum, was able to impair the intrahepatic cycle of the parasite. Expand
A Peculiar Mutation Spectrum Emerging from Young Peruvian Patients with Hepatocellular Carcinoma
TLDR
The results confirm the specificity of Peruvian hepatocellular carcinoma at the molecular genetic level and support the theory of a consistent collapse in the Hippo axis, as well as an expression of the stemness factor NANOG in high alpha-fetoprotein-expressing hepato cellular carcinomas. Expand
Quassia amara L. (Simaroubaceae) leaf tea: effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation.
TLDR
In French Guiana, Quassia amara L. (Simaroubaceae) leaf tea is a well-known widely used traditional antimalarial remedy, and tea made with dried juvenile (DJ) leaves displays a peculiar behavior, which enhances the expected curative effect of the traditional preparation. Expand
Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.
TLDR
This preparation should not be recommended for treatment of malaria until a clinical study in humans is performed with SkD, and both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD. Expand
Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.
TLDR
Drug interaction study following fractional inhibitory concentrations (FIC) method showed antagonism with amodiaquine, atovaquone, doxycycline, pyrimethamine; additivity with artemether, chloroquine, mefloquines, primaquine and synergy with quinine, which confirmed the interest of MB that could be integrated in a new low cost antimalarial combination therapy. Expand
An Atypical Age-Specific Pattern of Hepatocellular Carcinoma in Peru: A Threat for Andean Populations
TLDR
Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations, suggesting two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. Expand
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden
TLDR
It is concluded that in Peru, and maybe in other populations with Americas’ indigenous ancestry, HBV-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. Expand
Discordant Temporal Evolution of Pfcrt and Pfmdr1 Genotypes and Plasmodium falciparum In Vitro Drug Susceptibility to 4-Aminoquinolines after Drug Policy Change in French Guiana
TLDR
The molecular parameters studied did not account for the regained in vitro susceptibility to chloroquine and showed a poor correlation with susceptibility to artemether, lumefantrine, or quinine, and identification of novel markers of resistance to these antimalarials is needed in this South American area. Expand
Hepatocellular carcinoma surgery outcomes in the developing world: A 20-year retrospective cohort study at the National Cancer Institute of Peru
TLDR
It appears that staging systems and associated therapeutic algorithms designed for use in the developed world remain inadequate in certain populations, especially in the context of Peruvian patients, and clinicians in the developing world should reconsider management guidelines pertaining to hepatocellular carcinoma. Expand
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