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Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data
TLDR
A method that corrects contamination with normal cells and adjusts for genomes of different sizes so that the actual copy number of each region can be estimated, and proves a powerful tool when analysing publicly available data from two cell lines.
Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait
TLDR
A smooth transition from swimming to crawling is revealed, marked by a linear relationship between key locomotion metrics, and it is shown that environmental forces play only a small role in determining the shape of the worm, placing conditions on the minimal pattern of internal forces driving locomotion.
Characterization of WRKY co-regulatory networks in rice and Arabidopsis
TLDR
This work identified sets of co-expressed WRKY genes in both rice and Arabidopsis that are functionally likely to cooperate in the same signal transduction pathways, contributing to unveil gene cooperation pathways not yet identified by classical genetic analyses.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Next-generation sequencing for simultaneous determination of human papillomavirus load, subtype, and associated genomic copy number changes in tumors.
TLDR
Next-generation sequencing for the detection of HPV provides a multiplicity of data with clinical significance in a single test and demonstrates the ability of this method to detect other HPV subtypes that would not have been detected by traditional methods.
A novel genomic signature reclassifies an oral cancer subtype
TLDR
The largest and most detailed genomic and transcriptomic analysis yet performed on OVC, which, as an example of non‐metastatic cancer, may shed light on the nature of metastases, concludes that OVC is not a subtype of OSCC, but should be classified as a distinct entity.
C. elegans locomotion: a unified multidisciplinary perspective
Address: 1School of Computing, University of Leeds, Leeds LS2 9JT, UK, 2School of Physics, University of Leeds, Leeds LS2 9JT, UK, 3Bioelectronics Research Centre, Department of Electronics and
EU-OSTID: A Collection of Transposon Insertional Mutants for Functional Genomics in Rice
TLDR
A collection of 1373 unique flanking sequence tags, generated from Ac/Ds and Ac transposon lines for reverse genetics studies, were produced in japonica and indica rice and found to be distributed evenly over the entire rice genome with a distinct bias for predicted gene-rich regions.
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