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Chemical and biological aspects of Amaryllidaceae alkaloids
First isolated from Galanthus species, this alkaloid is a long-acting, selective, reversible and competitive inhibitor of acetylcholinesterase, and is used for the treatment of Alzheimer?s disease. Expand
Antiproliferative Alkaloids from Crinum zeylanicum
Crinum zeylanicum is used in folk medicine as a rubefacient in rheumatism, a treatment for malaria or as a poison. Complex alkaloid profiles in C. zeylanicum plant organs were revealed by GC‐MSExpand
Bioactive alkaloid extracts from Narcissus broussonetii: mass spectral studies.
Analytical methods were applied to study the alkaloid profile of Narcissus broussonetii, a plant endemic to North Africa, and found to be similar for obliquine and plicamine but different for secoplicamine, and the silylated tazettine and pretzettine were studied by GC-MS/MS, and finding to differ in their fragmentation routes. Expand
Alkaloid Spectrum in Diploid and Tetraploid Hairy Root Cultures of Datura stramonium
Hairy root cultures were obtained from diploid and induced tetraploid plants of Datura stramonium and analyzed by gas chromatography/mass spectrometry and a new tropane ester 3-tigloyloxy-6-propionyloxy-7-hydroxytropane was identified on the basis of mass spectral data. Expand
Development and validation of a GC-MS method for rapid determination of galanthamine in Leucojum aestivum and Narcissus ssp.: a metabolomic approach.
The analytical method developed and validated for galanthamine quantification by GC-MS proved to be simple, sensitive and far more informative than the routine analytical methods, so it may be useful for quality control of plant raw materials in the pharmaceutical industry. Expand
Plant Sources of Galanthamine: Phytochemical and Biotechnological Aspects
The phytochemical and biotechnological aspects of plants currently used for galanthamine production, namely Leucojum aestivum, Narcissus ssp. Expand
Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts.
Corydaline, bulbocapnine and stylopine were found to be active in the extracts of plant species of the families Fumariaceae and Papaveraceae, and galanthamine was isolated from the known AChE inhibitors in the extract of Amaryllidaceae plants. Expand
Alkaloid Diversity in Galanthus elwesii and Galanthus nivalis
The results from year‐to‐year sampling and transplantation experiments imply genetic determination of alkaloid synthesis in the two studied species of Galanthus. Expand
Alkaloid metabolite profiles by GC/MS and acetylcholinesterase inhibitory activities with binding-mode predictions of five Amaryllidaceae plants.
A combined strategy based on AChE-inhibitory activity and chemical profiles by GC/MS, together with in silico studies, suggested that the alkaloids 3-epimacronine and lycoramine might be of interest for A cholinesterase inhibition. Expand
Neuroprotective activity and acetylcholinesterase inhibition of five Amaryllidaceae species: a comparative study.
The results suggest that the neuroprotective effects might be associated with lycorine and crinine-type alkaloids, whereas the acetylcholinesterase enzyme inhibitory activity could be related to galanthamine and Lycorine- type alkalids, although not based on synergistic processes. Expand