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Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia.
- E. Asevedo, A. Gadelha, +10 authors E. Brietzke
- Psychology, Medicine
- Journal of psychiatric research
- 1 October 2013
OBJECTIVE To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the… Expand
Effects of Risperidone on Cytokine Profile in Drug-Naïve First-Episode Psychosis
- C. Noto, V. Ota, +9 authors E. Brietzke
- Medicine, Psychology
- The international journal of…
- 22 January 2015
Background: There is robust evidence that schizophrenia is characterized by immune-inflammatory abnormalities, including variations on cytokine levels. The results of previous studies, however, are… Expand
Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
In schizophrenia, genetic and environmental factors affect neurodevelopment and neuroprogressive trajectory. Altered expression of neuro-immune genes and increased levels of cytokines are observed,… Expand
Oxidative stress in drug naïve first episode psychosis and antioxidant effects of risperidone.
BACKGROUND Schizophrenia is accompanied by increased lipid peroxidation and nitric oxide (NO) levels and by lowered antioxidant levels. However, the effect of antipsychotic agents on these processes… Expand
Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis
- V. Ota, C. Noto, M. Santoro, L. Spindola, S. Belangero
- Psychology, Medicine
- European Neuropsychopharmacology
- 1 December 2015
Schizophrenia is a multifactorial neurodevelopmental disorder with high heritability. First-episode psychosis (FEP) is a critical period for determining the disease prognosis and is especially… Expand
Chromosomal and molecular abnormalities in a group of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia attending an infertility service.
- F. Mafra, D. Christofolini, +4 authors C. Barbosa
- International braz j urol : official journal of…
- 1 March 2011
PURPOSE To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia. MATERIALS AND METHODS Retrospective… Expand
Early life adversity, genomic plasticity, and psychopathology.
- G. Turecki, V. Ota, S. Belangero, A. Jackowski, J. Kaufman
- The lancet. Psychiatry
- 1 November 2014
Child maltreatment is associated with an increased risk of psychiatric disorders, and a range of health problems later in life. Research suggests that adverse events early in life can lead to changes… Expand
Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia.
BACKGROUND Schizophrenia (SZ) has been associated with an imbalance in the inflammatory cytokine TNF-α. The objectives of this study were to compare TNF-α and its soluble receptors' serum levels in… Expand
Association of biomarkers and depressive symptoms in schizophrenia
Emergence of depressive symptoms in schizophrenia results in a deteriorating course and poor prognosis. Schizophrenia and depressive disorder are both associated with low levels of brain-derived… Expand
Changes in gene expression and methylation in the blood of patients with first-episode psychosis
Schizophrenia is a severe mental health disorder with high heritability. The investigation of individuals during their first-episode psychosis (FEP), before the progression of psychotic disorders and… Expand