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Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
TLDR
The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls. Expand
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
TLDR
The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route and work that may provide a basis for development of anticoronaviral drugs. Expand
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
TLDR
The etymological derivation of individual names, their pronunciation, and their correct use are explained, and demarcation criteria for each taxon and virus are elaborate. Expand
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
TLDR
The results show that it is possible to interrogate the memory repertoire of immune donors to rapidly and efficiently isolate neutralizing antibodies that have been selected in the course of natural infection. Expand
DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus
TLDR
DC-SIGN and DC-SIGNR enhance infection mediated by the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus and might promote viral dissemination. Expand
SARS — beginning to understand a new virus
TLDR
The genomics of the Sars coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again are reviewed. Expand
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
TLDR
A phase 1/2, single-blind, randomised controlled trial in five trial sites in the UK of a chimpanzee adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein compared with a meningococcal conjugate vaccine as control to assess efficacy, reactogenicity, and cellular and humoral immune responses. Expand
Involvement of NADPH Oxidase Isoforms and Src Family Kinases in CD95-dependent Hepatocyte Apoptosis*
TLDR
The data suggest that CD95L-induced apoptosis involves a sphingomyelinase- and PKCζ-dependent activation of NADPH oxidase isoforms, which is required for Yes/EGFR/CD95 interactions as upstream events of CD95 activation. Expand
Investigating the zoonotic origin of the West African Ebola epidemic
TLDR
The range of possible Ebola virus sources is expanded to include insectivorous bats and the importance of broader sampling efforts for understanding Ebola virus ecology is reiterated. Expand
The Matrix Protein VP40 from Ebola Virus Octamerizes into Pore-like Structures with Specific RNA Binding Properties
TLDR
The crystal structure of a disk-shaped octameric form of VP40 formed by four antiparallel homodimers of the N-terminal domain is presented, which suggests that VP40 has an additional function in the life cycle of the virus besides promoting virus assembly and budding off the plasma membrane. Expand
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