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BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons
BackgroundVisualisation of genome comparisons is invaluable for helping to determine genotypic differences between closely related prokaryotes. New visualisation and abstraction methods are requiredExpand
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Easyfig: a genome comparison visualizer
Summary: Easyfig is a Python application for creating linear comparison figures of multiple genomic loci with an easy-to-use graphical user interface. Expand
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution
The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genomeExpand
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An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination
Several pathogenic strains of Escherichia coli exploit type III secretion to inject “effector proteins” into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. WeExpand
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Global dissemination of a multidrug resistant Escherichia coli clone
Significance Escherichia coli sequence type 131 (ST131) is a globally disseminated multidrug-resistant clone associated with human urinary tract and bloodstream infections. Here, we have used genomeExpand
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Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa
The onset of prezygotic and postzygotic barriers to gene flow between populations is a hallmark of speciation. One of the earliest postzygotic isolating barriers to arise between incipient species isExpand
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Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion
BackgroundLike many other pathogens, enterohaemorrhagic and enteropathogenic strains of Escherichia coli employ a type-III secretion system to translocate bacterial effector proteins into host cells,Expand
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Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perspective.
We review the biology of non-flagellar type-III secretion systems from a Darwinian perspective, highlighting the themes of evolution, conservation, variation and decay. The presence of these systemsExpand
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A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407.
In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominantExpand
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FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa.
Under conditions of iron limitation, Pseudomonas aeruginosa secretes a high-affinity siderophore pyoverdine to scavenge Fe(III) in the extracellular environment and shuttle it into the cell. UptakeExpand
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