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Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction.
TLDR
Results suggest that DR may lower REE independent of the DR-induced changes in body composition, and whether this reduction in REE contributes to the life-extending properties of DR warrants further analysis. Expand
Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys.
TLDR
PA males do not exhibit elevated androgens during adulthood, suggesting that insulin resistance and impaired pancreatic beta-cell function may result from fetal reprogramming of key metabolic tissues. Expand
Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure, in Obese, Insulin-Resistant Rhesus Monkeys
TLDR
Pioglitazone hydrochloride significantly improved fasting and postprandial levels of IRI, plasma glucose, and TG in a dose-related manner and was more marked for those animals with fasting hyperglycemia. Expand
Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
TLDR
The relationship between the timing of prenatal androgen exposure and body composition phenotypes in this nonhuman primate model for PCOS may provide insight into the heterogeneity of metabolic defects found in PCOS women. Expand
Insulin levels, physical activity, and urinary catecholamine excretion of obese and non-obese rhesus monkeys.
TLDR
The results suggest that hyperinsulinemia associated with obesity in rhesus monkeys is linked to increased catecholamine secretion and a resistance to catechlaminergic action. Expand
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys.
TLDR
Identification of the mechanisms through which these effects are achieved may aid in ameliorating glucose intolerance, insulin resistance, and associated illnesses in older persons. Expand
Reference body composition in adult rhesus monkeys: glucoregulatory and anthropometric indices.
TLDR
Body mass indices for underweight and obesity in rhesus monkeys were defined and insulin sensitivity index and disposition index reached minimum values at 23% fat in older males, 18% in adult females, and 21% in younger adult males, indicating obesity. Expand
Glucose regulation in captivePongo pygmaeus abeli, P. p. pygmaeus,andP. p. abeli x P. p. pygmaeusorangutans
TLDR
Nearly half of the animals of varying ages, all sub-species and both sexes exhibited delayed or attenuated acute insulin responses during the IVGTTs, suggesting propensity for glucose intolerance in captive orangutans. Expand
Age and sex differences in body size and composition during Rhesus monkey adulthood
TLDR
Data derived from adult nonhuman primates are useful for defining fundamental biological changes with age in these species, and have value as a comparative model for studies of human aging and age-related morbidity. Expand
Long-term calorie restriction decreases metabolic cost of movement and prevents decrease of physical activity during aging in rhesus monkeys
TLDR
The results suggest that long-term CR decreases basal metabolic rate, but maintains higher physical activity with lower metabolic cost of movements compared with C. Expand
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