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Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort.
TLDR
Risk of early neurological deterioration and of 3-month death was severely increased after PH2, indicating that large hematoma is the only type of hemorrhagic transformation that may alter the clinical course of ischemic stroke.
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
TLDR
There were no increases in either clinical relapses or in new enhancing lesions in any patient, even those with hypersensitivity reactions, and secondary analysis showed that the volume and number of enhancing lesions were reduced at a dose of 5 mg.
The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis
Randomized placebo-controlled trial of mitoxantrone in relapsing-remitting multiple sclerosis: 24-month clinical and MRI outcome
TLDR
It is suggested that mitoxantrone might be effective in reducing disease activity, both by decreasing the mean number of exacerbations and by slowing the clinical progression sustained by most patients after 1 year from the end of treatment.
Acute stroke: usefulness of early CT findings before thrombolytic therapy.
TLDR
The response to rt-PA in patients with ischemic stroke can be predicted on the basis of initial CT findings of the extent of parenchymal hypoattenuation in the territory of the middle cerebral artery.
‘Gender gap’ in multiple sclerosis: magnetic resonance imaging evidence
TLDR
The data indicate that men with MS are prone to develop less inflammatory, but more destructive lesions than women.
Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing–remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple
TLDR
Assessment of cognitive function at diagnosis could facilitate the identification of patients who may benefit from therapeutic intervention with disease-modifying therapies to prevent further lesion development.
Results of a prospective study (CATS) on the effects of thalamic stimulation in minimally conscious and vegetative state patients.
TLDR
It is confirmed that bilateral thalamic stimulation can improve the clinical status of patients affected by a disorder of consciousness, even though this stimulation did not induce persistent, clinically evident conscious behavior in the patients.
Early prediction of irreversible brain damage after ischemic stroke at CT.
TLDR
After isChemic stroke, x-ray hypoattenuation at CT is highly specific for irreversible ischemic brain damage if detection occurs within the first 6 hours.
ICHD-II Diagnostic Criteria for Tolosa—Hunt Syndrome in Idiopathic Inflammatory Syndromes of the Orbit and/or the Cavernous Sinus
TLDR
It is concluded that THS diagnostic criteria can be improved on the basis of currently available data and MRI should play a pivotal role both to diagnose and to follow-up THS.
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