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A comparative study of biocatalysis in non-conventional solvents: Ionic liquids, supercritical fluids and organic media
The catalytic activities of cutinase immobilized on zeolite NaY and Candida antarctica lipase B immobilized on an acrylic resin (Novozym 453) were measured in a model transesterification reaction inExpand
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Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systems.
A therapeutic deep eutectic system (THEDES) is here defined as a deep eutectic solvent (DES) having an active pharmaceutical ingredient (API) as one of the components. In this work, THEDESs areExpand
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A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: Solubility and permeability studies
&NA; THEDES, so called therapeutic deep eutectic solvents are here defined as a mixture of two components, which at a particular molar composition become liquid at room temperature and in which oneExpand
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From coffee industry waste materials to skin-friendly products with improved skin fat levels
Faculty of Pharmacy Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL) University of Lisbon
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Production of polyhydroxyalkanoates from spent coffee grounds oil obtained by supercritical fluid extraction technology.
Spent coffee grounds (SCG) oil was obtained by supercritical carbon dioxide (scCO2) extraction in a pilot plant apparatus, with an oil extraction yield of 90% at a 35kgkg(-1) CO2/SCG ratio.Expand
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Design of controlled release systems for THEDES-Therapeutic deep eutectic solvents, using supercritical fluid technology.
Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), andExpand
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Novozym 435 Activity in Compressed Gases. Water Activity and Temperature Effects
Abstract The transesterification reaction of n -butyl acetate by 1-hexanol catalyzed by Novozym 435 (immobilized Candida antarctica lipase B from Novo Nordisk) suspended in near-critical carbonExpand
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Effect of immobilization support, water activity, and enzyme ionization state on cutinase activity and enantioselectivity in organic media
We studied the reaction between vinyl butyrate and 2‐phenyl‐1‐propanol in acetonitrile catalyzed by Fusarium solani pisi cutinase immobilized on zeolites NaA and NaY and on Accurel PA‐6. The choiceExpand
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Biocatalytic separation of (R, S)-1-phenylethanol enantiomers and fractionation of reaction products with supercritical carbon dioxide
Abstract The continuous kinetic resolution of (R, S)-1-phenylethanol via enzymatic transesterification was chosen as a benchmark reaction for the study of a complete reaction/separation process usingExpand
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Sol-gel encapsulation: an efficient and versatile immobilization technique for cutinase in non-aqueous media.
Cutinase from Fusarium solani pisi was encapsulated in sol-gel matrices prepared with a combination of alkyl-alkoxysilane precursors of different chain-lengths. The specific activity of cutinase in aExpand
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