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Mortality in systemic lupus erythematosus.
OBJECTIVE To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS Our sample was a multisite international SLE cohort (23 centers, 9,547… Expand
An international cohort study of cancer in systemic lupus erythematosus.
OBJECTIVE There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but in earlier studies the association could not be quantified… Expand
Cancer risk in systemic lupus: an updated international multi-centre cohort study.
OBJECTIVE To update estimates of cancer risk in SLE relative to the general population. METHODS A multisite international SLE cohort was linked with regional tumor registries. Standardized… Expand
Damage in systemic lupus erythematosus and its association with corticosteroids.
OBJECTIVE To evaluate the association between corticosteroid use and organ damage in patients with systemic lupus erythematosus (SLE). METHODS The occurrence and date of organ damage, as measured… Expand
The relationship between cancer and medication exposures in systemic lupus erythaematosus: a case–cohort study
Objective: To examine if, in systemic lupus erythaematosus (SLE), exposure to immunosuppressive therapy (cyclophosphamide, azathioprine, methotrexate) increases cancer risk. Methods: A case–cohort… Expand
The global burden of SLE: prevalence, health disparities and socioeconomic impact
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can potentially lead to serious organ complications and even death. Its global burden — in terms of incidence and… Expand
Patterns of disease activity in systemic lupus erythematosus.
OBJECTIVE To describe patterns of systemic lupus (SLE) disease activity over time. METHODS Disease activity was measured in a prospective cohort of 204 consecutive SLE patients followed up… Expand
A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Multiple genetic and environmental factors contribute to the pathogenesis of this disease. Recent genome-wide association… Expand
Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes.
Isolated mouse hepatocytes were incubated with 1.0 mM acetaminophen (AA) for 1.5 h to initiate glutathione (GSH) and protein thiol (PSH) depletion and cell injury. Cells were subsequently washed to… Expand
Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus.
OBJECTIVE To determine the degree to which changes in anti-double-stranded DNA (anti-dsDNA), as determined by Crithidia and enzyme-linked immunosorbent assays (ELISAs), precede or coincide with… Expand