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Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella
A group of highly immunogenic surface-exposed proteins of nontypeable H. influenzae which are related to the filamentous hemagglutinin of B. pertussis are identified and partially characterized. Expand
Efficacy of an acellular pertussis vaccine among adolescents and adults.
The acellular pertussis vaccine was protective among adolescents and adults, and its routine use might reduce the overall disease burden and transmission to children. Expand
Genetic relationships of serologically nontypable and serotype b strains of Haemophilus influenzae
A collection of 242 strains of Haemophilus influenzae, including 65 nontypable (unencapsulated) isolates and 177 encapsulated serotype b isolates recovered largely from children with invasive andExpand
Prevalence and distribution of the hmw and hia genes and the HMW and Hia adhesins among genetically diverse strains of nontypeable Haemophilus influenzae.
The prevalence and distribution of the hmw and hia genes in a collection of 59 nontypeable strains previously characterized in terms of genetic relatedness were determined and it was established that the IS1016 insertion element was uniformly absent from strains containing hmW sequences but was present in two-thirds of thehmw-deficient strains. Expand
The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis
It is concluded that glycosylation is a prerequisite for H MW1 stability and appears to be essential for optimal HMW1 tethering to the bacterial surface, which in turn is required for HMW 1‐mediated adherence, thus revealing a novel mechanism by which gly cosylation influences cell–cell interactions. Expand
Recurrent Variable Region Gene Usage and Somatic Mutation in the Human Antibody Response to the Capsular Polysaccharide of Streptococcus pneumoniae Type 23F
It is determined that, in spite of the combinatorial diversity available to the immune system, the 23F-specific response is highly restricted at the population level, with the same two L-chain-determined paratope families recurring in all individuals. Expand
Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles.
Comparison of the major outer-membrane proteins of H. influenzae type b is a useful technique for investigating the transmission of the organism and may provide a basis for further immunologic characterization of the outer- MEMB proteins. Expand
Randomized, controlled trial of antibiotics in the management of community-acquired skin abscesses in the pediatric patient.
Antibiotics are not required for pediatric skin abscess resolution and may help prevent new lesions in the short term, but further studies are required. Expand
Severe Community-acquired Pneumonia Due to Staphylococcus aureus, 2003–04 Influenza Season
A confirmed case of St. aureus community-acquired pneumonia in the U.S. has been reported from 9 states, and the number of cases is likely to increase as more people are diagnosed with the disease. Expand
Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates.
Although the P2 protein from isolates with different OMP subtypes are closely related, the protection experiments suggest that determinants on the cell surface interacting with protective antibody may be strain or subtype specific. Expand