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Functional reorganization of the rat motor cortex following motor skill learning.
Results demonstrate that motor skill learning is associated with a reorganization of movement representations within the rodent motor cortex. Expand
Extensive Cortical Rewiring after Brain Injury
The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target, and support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization. Expand
Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery.
It is suggested that neurophysiologic reorganization of remote cortical areas occurs in response to cortical injury and that the greater the damage to reciprocal intracortical pathways, the great the plasticity in intact areas. Expand
Motor Learning-Dependent Synaptogenesis Is Localized to Functionally Reorganized Motor Cortex
This is the first demonstration of the co-occurrence of functional and structural plasticity within the same cortical regions and provides strong evidence that synapse formation may play a role in supporting learning-dependent changes in cortical function. Expand
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates
Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. Expand
A Battery-Powered Activity-Dependent Intracortical Microstimulation IC for Brain-Machine-Brain Interface
This paper describes an activity-dependent intracortical microstimulation (ICMS) system-on-chip (SoC) that converts extracellular neural spikes recorded from one brain region to electrical stimuliExpand
Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey.
Data suggest that, at least in squirrel monkeys, descending output from M1 and dorsal and ventral premotor cortices is not necessary for SMA representations to be maintained and that SMA motor output maps undergo delayed increases in representational area after damage to other motor areas. Expand
Restoration of function after brain damage using a neural prosthesis
The results show that by using discriminated action potentials as a trigger for stimulating a distant cortical location, rapid recovery of fine motor skills is facilitated, providing strong evidence that BMBIs can be used to bridge damaged neural pathways functionally and promote recovery after brain injury. Expand
Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.
The results suggest that after a lesion in the M1 DFL, the induction of representational plasticity in PMv, as evaluated using intracortical microstimulation, is related more to the size of the lesion than to the disruption of its intrACortical connections. Expand
Ipsilateral connections of the ventral premotor cortex in a new world primate
The present study describes the pattern of connections of the ventral premotor cortex (PMv) with various cortical regions of the ipsilateral hemisphere in adult squirrel monkeys. Particularly, we 1)Expand