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“Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB‐FUBINACA in New York
- A. Adams, S. Banister, Lisandro Irizarry, J. Trecki, M. Schwartz, R. Gerona
- MedicineThe New England journal of medicine
- 19 January 2017
The potency of the synthetic cannabinoid identified in these analyses is consistent with strong depressant effects that account for the “zombielike” behavior reported in this mass intoxication in New York City.
Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.
In vitro and in vivo data indicate that these SCs act as highly efficacious CB receptor agonists with greater potency than Δ(9)-THC and earlier generations of SCs.
Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.
In vitro functional activities of SC designer drugs JWH-018, UR-144, PB-22, and APICA, and their respective terminally fluorinated analogues and in vivo in vivo cannabinoid type 1 receptor binding affinity evaluated in rats showed no consistent trend for increased potency of fluorinated SCs over the corresponding des-fluoro SCs in vivo.
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA.
Synthetic cannabinoid designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains and several analogues are synthesized and characterized, indicating that these SCs are cannabimimetic in vivo, consistent with anecdotal reports of psychoactivity in humans.
Detection of the recently emerged synthetic cannabinoid 5F-MDMB-PICA in 'legal high' products and human urine samples.
Exemplary analysis of one urine sample for 5F-MDMB-PICA phase II metabolites showed that two of the main phase I metabolites are subject to extensive glucuronidation prior to renal excretion, and conjugate cleavage is reasonable for enhancing sensitivity.
Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome
- Vanessa Liang, Milena Ullrich, H. Nicholas
- BiologyCellular and Molecular Life Sciences
- 24 January 2014
Interestingly, although the net rate of protein synthesis is reduced in aged animals, the analyses indicate that the synthesis of certain proteins such as the vitellogenins increases with age.
[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats
The results suggest that, with the longer half-life of [ 18F] which facilitates distribution of the tracer across PET centre, [18F]DPA-714 is a good alternative for TSPO imaging.
Could 18 F-DPA-714 PET imaging be interesting to use in the early post-stroke period?
18 F-DPA-714 may be useful in assessing the extent of neuroinflammation associated with acute stroke and could also help to predict clinical outcomes and functional recovery, as well as to assess therapeutic strategies, such as the use of neuroprotective/anti-inflammatory drugs.
Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA.
Five scaffold-hopping SCRAs, including 5F-CUMYL-P7AICA, were synthesized and characterized and found to exert potent cannabimimetic effects in mice, inducing hypothermia through a CB1 -dependent mechanism.