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Lysosome-targeting chimaeras for degradation of extracellular proteins
The results establish a modular strategy for directing secreted and membrane proteins for lysosomal degradation, with broad implications for biochemical research and for therapeutics.
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
Lysosome-targeting chimeras based on glycan ligands of the asialoglycoprotein receptor facilitate the cell-specific targeting and turnover of proteins by lysosomal enzymes, expanding the scope of LYTAC-mediated targeted protein degradation.
Effect of Nanoscale Morphology on the Conductivity of Polymerized Ionic Liquid Block Copolymers
Polymerized ionic liquid (POIL) block copolymers represent a unique class of materials for fundamental studies of single ion conduction as a function of morphology in microphase-separated polymer
Lysosome Targeting Chimeras (LYTACs) for the Degradation of Secreted and Membrane Proteins
It is demonstrated that LYTACs mediate efficient degradation of Apolipoprotein-E4, epidermal growth factor receptor (EGFR), CD71, and programmed death-ligand 1 (PD-L1).
Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus
This work constructed a synthetic glycocalyx to investigate membrane-tethered mucins in the context of IAV binding and fusion and observed that while fusion of virions bound to vesicles coated with sialylated mucin mimics was possible, the kinetics of fusion was slowed in a mucin density-dependent manner.
Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters
A method for the catalytic, asymmetric, migratory geminal difluorination of β-substituted styrenes to access a variety of products bearing diffluoromethylated tertiary or quaternary stereocenters is reported.
Catalytic, Diastereoselective 1,2-Difluorination of Alkenes.
We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is
Lewis acid enhancement by hydrogen-bond donors for asymmetric catalysis
A mode of catalytic activity with chiral H-bond donors that enables enantioselective reactions of relatively unreactive electrophiles, and squaramides are shown to interact with silyl triflates by binding the triflate counterion to form a stable, yet highly Lewis acidic, complex.
Chemoselective Pd-catalyzed oxidation of polyols: synthetic scope and mechanistic studies.
Density functional theory calculations support the conclusion that β-hydride elimination to give hydroxy ketones is product-determining for the oxidation of vicinal diols, whereas for primary and secondary alcohols, pre-equilibria favoring primary alkoxides are product-Determining.
Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source.
The enantioselective synthesis of 4-fluoroisochromanones via chiral aryl iodide-catalyzed fluorolactonization is reported, and the regioselectivity observed in these lactonization reactions is complementary to that obtained with established asymmetric electrophilic fluorination protocols.