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Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
We here report biomagnification (the increasing accumulation of bioactive, often deleterious molecules through higher trophic levels of a food chain) of the neurotoxic nonprotein amino acidExpand
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A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam.
As root symbionts of cycad trees, cyanobacteria of the genus Nostoc produce beta-methylamino-l-alanine (BMAA), a neurotoxic nonprotein amino acid. The biomagnification of BMAA through the GuamExpand
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Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid.
Cyanobacteria can generate molecules hazardous to human health, but production of the known cyanotoxins is taxonomically sporadic. For example, members of a few genera produce hepatotoxicExpand
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Occurrence of β‐methylamino‐l‐alanine (BMAA) in ALS/PDC patients from Guam
We tested the brain tissues of the Chamorro people of Guam who died of amyotrophic lateral sclerosis/Parkinsonism dimentia complex (ALS/PDC) for the neurotoxin β‐methylamino‐l‐alanine (BMAA). We usedExpand
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Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease
Objective –  The aim of this study was to screen for and quantify the neurotoxic amino acid β‐N‐methylamino‐l‐alanine (BMAA) in a cohort of autopsy specimens taken from Alzheimer’s disease (AD),Expand
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Biomagnification of cycad neurotoxins in flying foxes
β-Methylamino-l-alanine (BMAA) occurs in higher levels in museum specimens of the Guamanian flying fox than in the cycad seeds the flying foxes feed on, confirming the hypothesis that cycadExpand
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The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation
Mechanisms of protein misfolding are of increasing interest in the aetiology of neurodegenerative diseases characterized by protein aggregation and tangles including Amyotrophic Lateral SclerosisExpand
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Production of the Neurotoxin BMAA by a Marine Cyanobacterium
Diverse species of cyanobacteria have recently been discovered to produce the neurotoxic non-protein amino acid β-methylamino-L-alanine (BMAA). In Guam, BMAA has been studied as a possibleExpand
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Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
Neurofibrillary tangles (NFT) and β-amyloid plaques are the neurological hallmarks of both Alzheimer's disease and an unusual paralytic illness suffered by Chamorro villagers on the Pacific island ofExpand
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