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Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations.
Human mitochondrial DNAs (mtDNAs) from 153 independent samples encompassing seven Asian populations were surveyed for sequence variation using the polymerase chain reaction (PCR), restrictionExpand
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Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Abstract Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes, cancer and neurodegeneration.Expand
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Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
Diabetes mellitus (DM) is one of the most common chronic disorders of children and adults. Several reports have suggested an increased incidence of maternal transmission in some forms of DM.Expand
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Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion andExpand
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Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis.
More than 100 million people in the United States live in areas that exceed current ozone air quality standards. In addition to its known pulmonary effects, environmental ozone exposures have beenExpand
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Mitochondrial dysfunction in cardiovascular disease.
  • S. Ballinger
  • Biology, Medicine
  • Free radical biology & medicine
  • 15 May 2005
Whereas the pathogenesis of atherosclerosis has been intensively studied and described, the underlying events that initiate cardiovascular disease are not yet fully understood. A substantial numberExpand
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The Bioenergetic Health Index: a new concept in mitochondrial translational research
Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration,Expand
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Mitochondrial DNA analysis of hybridization between sympatric white-tailed deer and mule deer in west Texas.
Sympatric populations of white-tailed deer and mule deer (Odocoileus virginianus and Odocoileus hemionus, respectively) on a west Texas ranch share a common mitochondrial DNA restriction mapExpand
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The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species,Expand
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Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells.
The mechanisms by which reactive species (RS) participate in the development of atherosclerosis remain incompletely understood. The present study was designed to test the hypothesis that RS producedExpand
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